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XIONG Peng, LI Guoliang, ZHU Mingchuang, ZHU Min. Research Progress of G Protein-coupled Receptor and Cancer[J]. Cancer Research on Prevention and Treatment, 2017, 44(12): 850-854. DOI: 10.3971/j.issn.1000-8578.2017.17.0262
Citation: XIONG Peng, LI Guoliang, ZHU Mingchuang, ZHU Min. Research Progress of G Protein-coupled Receptor and Cancer[J]. Cancer Research on Prevention and Treatment, 2017, 44(12): 850-854. DOI: 10.3971/j.issn.1000-8578.2017.17.0262

Research Progress of G Protein-coupled Receptor and Cancer

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  • Corresponding author:

    ZHU Min, E-mail: mzhu@tjh.tjmu.edu.cn

  • Received Date: March 12, 2017
  • Revised Date: September 22, 2017
  • Available Online: January 12, 2024
  • The G protein-coupled receptor (GPCR) family is the largest and most diverse family of membrane proteins in eukaryotes. It has seven α-helix transmembrane domains and a wide range of biological functions. In recent years, more and more studies have shown that the disorders of GPCRs are related to cancer, which may be involved in the development and progression of tumors as proto-oncogenes or tumor suppressor genes, and GPCR has a diverse signaling mechanism. This paper briefly summarizes the diverse signaling mechanism of GPCRs, and recent research progress of a number of GPCRs in the development and progression of tumor.

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