| Citation: |
JIN Long, FU Shenbo, YU Jiao. Effect of NLR and PLR from Pre-treatment on Prognosis of Nasopharyngeal Carcinoma Patients[J]. Cancer Research on Prevention and Treatment, 2017, 44(7): 476-480. DOI: 10.3971/j.issn.1000-8578.2017.16.1536
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To investigate the correlation of platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR) in the peripheral blood of nasopharyngeal carcinoma patients before treatment with their overall survival (OS), progression-free survival (PFS).
We retrospectively analyzed the clinical data of 91 nasopharyngeal carcinoma patients who received initial treatment in the First Affiliated Hospital of Xi'an Jiao Tong University and Shaanxi Provincial People's Hospital from January 2009 to September 2013. The patients were grouped on the basis of cutoff value of PLR and NLR according to ROC curve. Kaplan-Meier method and Log rank test were used to compare overall survival rates and progression free survival rates between different groups; meanwhile Cox proportional hazard model was used to analyze single factor and multiple factors.
When PLR=143.3 and NLR=2.6, the predictive value of patient's prognosis was the highest. Cox multivariate analysis showed that OS was shorter when PLR≥143.3 (RR=2.491, 95%CI=1.139-5.451, P=0.022) and NLR≥2.6(RR=2.186, 95%CI=1.021-4.682, P=0.044), and PFS was shorter when PLR≥143.3 (RR=2.461, 95%CI=1.242-4.874, P=0.01).
PLR and NLR before treatment may be the independent risk factors for the prognosis of nasopharyngeal carcinoma patients.
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