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LING Gengqiang, MA Dongying, HE Ruixing, WANG Yuena, YE Wei. Mechanism of All-trans Retinoic Acid Inhibiting Vasculogenic Mimicry Formation in Glioma Cell Line U87[J]. Cancer Research on Prevention and Treatment, 2017, 44(6): 377-380. DOI: 10.3971/j.issn.1000-8578.2017.16.1470
Citation: LING Gengqiang, MA Dongying, HE Ruixing, WANG Yuena, YE Wei. Mechanism of All-trans Retinoic Acid Inhibiting Vasculogenic Mimicry Formation in Glioma Cell Line U87[J]. Cancer Research on Prevention and Treatment, 2017, 44(6): 377-380. DOI: 10.3971/j.issn.1000-8578.2017.16.1470
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Mechanism of All-trans Retinoic Acid Inhibiting Vasculogenic Mimicry Formation in Glioma Cell Line U87

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    • Abstract
  • Objective To investigate the mechanism of all-trans retinoic acid (ATRA) inhibiting vasculogenic mimicry (VM) formation in glioma cell line U87.
    Methods We added different concentration of ATRA into U87 culture medium, in order to compare the VM forming ability, invading ability, NF-κB phosphorylation capacity and MMP-2 activity among groups via Tube formation tests, Transwell tests, Western blot tests and Zymography tests.
    Results Along with the elevation of ATRA concentration, the VM forming ability, invading ability, NF-κB phosphorylation capacity and MMP-2 activity all became weakened.
    Conclusion The mechanism of ATRA inhibiting VM formation in glioma cell line U87 might be due to the weakened cell invading ability, which was caused by decreased MMP-2 activity resulted from down-regulation of NF-κB signaling pathways.
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