Perioperative Security Evaluation of Intra-operative Radiotherapy for Recurrent Bone and Soft Tissue Sarcomas Around Pelvis

Objective To explore the perioperative security of intra-operative radiotherapy (IORT) for recurrent bone and soft tissue sarcomas around the pelvis.

Methods The patients with recurrent bone and soft tissue sarcomas around the pelvis that were treated in our hospital or outside by surgical operation were regarded as subjects. Fourty cases were screened finally and divided into preoperative radiotherapy combined with surgery resection group (n=20), named control group, and operation combined with IORT group (n=20, performed with extensive operation combined IORT). Some important intraoperative index, postoperative index, and complications of the two groups were compared after treatment.

Results There was 1 case with rectum and cystitis complication in operation combined with IORT group, but there were 6 cases in control group, the difference was statistically significant (P < 0.05); The blood loss of the patients in operation combined with IORT group was (946.33±66.27) ml, which was more than that in control group, (750.66±56.19) ml (P < 0.05). But the hospitalization time and suture removal time in operation combined with IORT group were (8.27±0.64) d and (13.53±0.65) d respectively that were significantly shorter than those in control group, (10.67±1.15) d and (16.17±0.76) d (P < 0.05). There was no significant difference on operation time, leucocyte count, wound cavity drainage, the case number of wound infection, or wound fat liquefaction between these two groups (P > 0.05).

Conclusion The evaluation of operation combined with IORT for recurrent bone and soft tissue sarcomas around the pelvis is good, safe and with fewer postoperative complications, but the long-term effect needs to be explored further.