Relationship of Serum IL-17, IL-35, SIL-2R Levels with Occurrence and Development of Thyroid Cancer

Objective  To detect the levels of IL-17, IL-35, SIL-2R in the serum, then to explore their relationship with the occurrence and development of thyroid cancer.

Methods  We used enzyme-linked immunosorbent(ELISA) to detect the plasma levels of IL-17, IL-35, SIL-2R in 67 cases of thyroid carcinoma, 30 cases of thyroid adenoma and 30 cases of healthy controls. And then we analyzed their correlation with age, gender, course of the disease, malignant degree of thyroid carcinoma and pathologic stage.

Results  The serum IL-17 and SIL-2R levels in the thyroid cancer group were significantly higher than those in the thyroid adenoma group and the control group(P＜0.05) . The level of serum IL-35 in the thyroid cancer group was significantly less than those in the thyroid adenoma group and the control group(P＜0.05) . With the decrease of differentiated degree of thyroid cancer, the serum levels of IL-17 and SIL-2R were increased, while the IL-35 level was decreased, and the comparison between each two groups had statistical difference(P＜0.05) . With the increase of thyroid cancer pathological staging, the serum levels of IL-17 and SIL-2R were on the rise, while the serum level of IL -35 showed a downward trend, and there were significant differences among different stages(P＜0.05) . But there was no significant difference between IL-17 and SIL-2R levels in the gender and age stratified analysis(P>0.05) .

Conclusion  Plasma IL-17, IL-35 and SIL-2R levels may be associated with the occurrence and development of thyroid cancer, and measuring their levels could be used as the important immunological indexes for clinical observation and monitoring curative effect.