Objective To investigate the clinicopathological features and the prognosis of metaplastic carcinoma of the breast with mesenchymal differentiation patients.
Methods We analyzed retrospectively the clinicopathological data of 28 metaplastic carcinoma of the breast with mesenchymal differentiation patients who were admitted from 2003 to 2013 in Tianjin Medical University Cancer Institute and Hospital. The survival rate was calculated by Kaplan-Meier analysis.
Results All patients were females aged 30-89 years(median age 53.5 years). The average maximum diameter of the tumor was 3.3cm. The positive rates of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (Her-2) were 10.7%, 10.7% and 3% respectively. In the follow-up visits, the recurrence or metastasis were found in eight patients, and six patients died of tumor recurrence and metastasis. The median follow-up was 40 months. Five-year overall survival rate and 5-year disease-free survival rate were 64.9 % and 61%, respectively.
Conclusion Metaplastic carcinoma of the breast with mesenchymal differentiation is highly invasive, with low rates of positive receptors and morbidity, early distant metastasis or recurrence after operation, and poor prognosis.
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