Progress of Epigenetic Modulators in Treatment of Breast Cancer

Recent researches on gene expression profiles linked to the different types of breast cancer cells have led to consider the use of epigenetic modulators to modulate the expression of genes deregulated in cancer. The preliminary encouraging results have demonstrated a positive effect of DNA methyl transferase and histone deacetylase inhibitors on different types of breast cancer,as well as drug-resistant cells. In this review,we will describe the different epigenetic modulators currently used or investigated in breast cancer therapy research in vitro as well as clinical trials,and promising compounds,which might be used in future breast cancer therapies.