Clinical Significance of Serum Levels of IGF-1 and CA153 in Patients with Recurrence of Breast Cancer

Objective To explore the clinical significance of serum IGF-1 and CA153 levels in patients with recurrence of breast cancer. Methods The serum levels of IGF-1 and CA153 in 169 patients with recurrence of breast cancer, 186 patients without recurrence of breast cancer were determined by ELISA and RIA respectively. Results The serum levels of IGF-1 and CA153 in patients with recurrence of breast cancer (183.3±33.6), (75.8±6.7) were significantly higher than those without recurrence of breast cancer (89.7±21.5), (16.9±4.3) (P<0.05). And the serum levels of IGF-1 were positively correlated with the levels of CA153 (r=0.67, P<0.05). Conclusion The postoperative change of serum levels of IGF-1 and CA153 in patients with breast cancer might be helpful to predict the recurrence of breast cancer.