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YAN Xiaolu, GAO Zhe, LI Qingxia. Clinical Significance of Serum Levels of IGF-1 and CA153 in Patients with Recurrence of Breast Cancer[J]. Cancer Research on Prevention and Treatment, 2015, 42(05): 481-482. DOI: 10.3971/j.issn.1000-8578.2015.05.013
Citation: YAN Xiaolu, GAO Zhe, LI Qingxia. Clinical Significance of Serum Levels of IGF-1 and CA153 in Patients with Recurrence of Breast Cancer[J]. Cancer Research on Prevention and Treatment, 2015, 42(05): 481-482. DOI: 10.3971/j.issn.1000-8578.2015.05.013
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Clinical Significance of Serum Levels of IGF-1 and CA153 in Patients with Recurrence of Breast Cancer

  • 1.Department of Oncology, The General Hospital of Hebei Province, Shijiazhuang 050051, China; 2. Department of Endocrinology, The General Hospital of Hebei Province,Shijiazhuang 050051, China

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  • Received Date: December 10, 2014
  • Revised Date: February 11, 2015
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    • Abstract
  • Objective To explore the clinical significance of serum IGF-1 and CA153 levels in patients with recurrence of breast cancer. Methods The serum levels of IGF-1 and CA153 in 169 patients with recurrence of breast cancer, 186 patients without recurrence of breast cancer were determined by ELISA and RIA respectively. Results The serum levels of IGF-1 and CA153 in patients with recurrence of breast cancer [(183.3±33.6), (75.8±6.7)] were significantly higher than those without recurrence of breast cancer [(89.7±21.5), (16.9±4.3) (P<0.05). And the serum levels of IGF-1 were positively correlated with the levels of CA153 (r=0.67, P<0.05). Conclusion The postoperative change of serum levels of IGF-1 and CA153 in patients with breast cancer might be helpful to predict the recurrence of breast cancer.
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    • References (8)
  • [1]
    Jemal A, Bray F, Center MM, et al.Global cancer statistics[J]. CA Cancer J Clin, 2011, 61(2): 134．
    [2]
    Zhuang H. Clinical significance of determination of serum CAl5- 3, CAl25 and VEGF levels after operation in patients with breast cancer[J]. Fang She Mian Yi Xue Za Zhi, 2010, 23(3): 260-1. [庄 浩. 乳腺癌患者手术治疗前后血清CAl5-3、CAl25和VEGF检 测的临床意义[J]. 放射免疫学杂志, 2010, 23(3): 260-1.]
    [3]
    Dupnt WD, Parl FF, Hartmann WH, et al. Breast cancer risk associated with proliferative breast diseases and atypical hyperplasia[J]. Cancer, 1993, 71(4): 1258-65.
    [4]
    Ren Y, Guo JG, Wu B. The diagnostic value of tumor markers and radionuclide bone imaging for bone metastases of breast cancer[J]. Fang She Mian Yi Xue Za Zhi, 2008, 21(2): 144-5. [任 嫒, 郭晋刚, 吴波. 肿瘤标记物和核素骨显像联检对乳腺癌骨转 移的诊断价值[J]. 放射免疫学杂志, 2008, 21(2): 144-5.]
    [5]
    Huang GL, Zhang JQ, Wu YP, et al. Influence of Neoadjuvant Chemotherapy on Insulin-Like Growth Factor-I Receptor expression of breast cancer patients[J]. Zhognguo Pu Wai Ji Chu Yu Lin Chuang Za Zhi, 2009, 16(l0): 834-7. [黄桂林, 张剑权, 吴 毅平, 等. 新辅助化疗对乳腺癌患者胰岛素样生长因子-1受体 表达的影响[J]. 中国普外基础与临床杂志, 2009, 16(l0): 834-7.]
    [6]
    Zatelli MC, Minoia M, Molb D, et al. Growth hormone express promotes breast career chemoresistanee[J]. J Clin Endocrinol Metab, 2009, 94(10): 3931-8.
    [7]
    Endogenous Hormones and Breast Cancer Collaborative Group, Key TJ, Appleby PN, et al．Insulin-like growth factor 1(IGF1), IGF binding protein 3(IGFBP3),and breast cancer risk: pooled individual data analysis of 17 prospective studies[J]. Lancet Oncol, 2010, 11(6): 530-42.
    [8]
    Zhang YY. Clinical significance of changes of serum VEGF，IGF-l levels in patients with breast cancer[J]. Fang She Mian Yi Xue Za Zhi, 2010, 23(6): 679-80. [张云燕. 乳腺癌患者血清VEGF、lGF-I 水平的变化及临床意义[J]. 放射免疫学杂志, 2010, 23(6): 679-80.]
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