Expression of HOX11 Gene in Acute Myeloid Leukemia Patients and Its Clinical Significance

Objective To investigate the expression of HOX11 gene in acute myeloid leukemia（AML）patients and its clinical significance for prognosis, to provide evidence for individualized therapy. Methods Multiplex nested RT-PCR was performed on 73 newly diagnosed AML patients to detect fusion genes. The effect of standardized therapy was analyzed on these patients who had positive or negative HOX11 expression. Results During the standardized therapy, the complete remission rate was not higher in HOX11-positive patients with favourable prognosis AML, secondary prognosis AML，and unfavourable prognosis AML than that in HOX11-negative patients after the first course of induction therapy (P>0.05),but relapse or mortality rate was higher in HOX11-positive patients(P<0.05). Conclusion The express of HOX11 may influence the prognosis of AML.