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GAO Fang, LU Lin, QIN Jindong, ZHANG Bin, LI Jingjing, ZHOU Chengjiang, JIA Yanbin. Single Nucleotide Polymorphism(SNP) in COX-2 Gene are Associated with Risk of Noncardia Gastric Cancer[J]. Cancer Research on Prevention and Treatment, 2015, 42(05): 470-473. DOI: 10.3971/j.issn.1000-8578.2015.05.010
Citation: GAO Fang, LU Lin, QIN Jindong, ZHANG Bin, LI Jingjing, ZHOU Chengjiang, JIA Yanbin. Single Nucleotide Polymorphism(SNP) in COX-2 Gene are Associated with Risk of Noncardia Gastric Cancer[J]. Cancer Research on Prevention and Treatment, 2015, 42(05): 470-473. DOI: 10.3971/j.issn.1000-8578.2015.05.010
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Single Nucleotide Polymorphism(SNP) in COX-2 Gene are Associated with Risk of Noncardia Gastric Cancer

  • 1. School of Medical Technology, Baotou Medical College, Baotou 014060, China; 2. Department of Laboratory, The First Affiliated Hospital of Baotou Medical College, Baotou 014060, China; 3. Department of Sports Rehabilitation, Baotou Medical College, Baotou 014060, China; 4. Department of Laboratory, The Third Worker Hospital of BAOGANG Group, Baotou 014060, China; 5. School of Basic Medicine, Baotou Medical College, Baotou 014060, China

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  • Received Date: July 22, 2014
  • Revised Date: November 18, 2014
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    • Abstract
  • Objective To investigate the relationship between single nucleotide polymorphism(SNP), rs689466, rs5275, rs4648308, in COX-2 gene and the risk of non-cardia gastric cancer. Methods Three tested SNPs were genotyped by TaqMan method among 288 patients with non-cardia gastric cancer and 281 normal controls. Haplotype was constructed by Haploview software. Odds ratio(OR) and 95% confidence intervals (95%CI) were measured by Logistic regression analysis to evaluate the correlations of the alleles, genotypes, and haplotypes with the susceptibility to non-cardia gastric cancer. Results SNP rs5275 C allele and rs4648308 A allele were significantly associated with an increased risk of non-cardia gastric cancer. And rs5275 CT, CC genotypes and rs4648308 GA genotype were also significantly associated with an increased risk of non-cardia gastric cancer (rs5275: CT vs. TT: OR=1.458, 95% CI: 1.015-2.096); CC vs. TT: OR=3.704, 95%CI: 1.184-11.59; rs4648308: GA vs. GG: OR=3.387, 95%CI:1.953-5.872). Furthermore, haplotype ACA was significantly associated with a higher risk of non-cardia gastric cancer, compared with GTG haplotype (OR=3.198, 95%CI: 1.854-5.516). Conclusion SNP rs5275 and rs4648308 in COX-2 gene are associated with the risk of non-cardia gastric cancer.
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