Advanced Search
GAO Fang, LU Lin, QIN Jindong, ZHANG Bin, LI Jingjing, ZHOU Chengjiang, JIA Yanbin. Single Nucleotide Polymorphism(SNP) in COX-2 Gene are Associated with Risk of Noncardia Gastric Cancer[J]. Cancer Research on Prevention and Treatment, 2015, 42(05): 470-473. DOI: 10.3971/j.issn.1000-8578.2015.05.010
Citation: GAO Fang, LU Lin, QIN Jindong, ZHANG Bin, LI Jingjing, ZHOU Chengjiang, JIA Yanbin. Single Nucleotide Polymorphism(SNP) in COX-2 Gene are Associated with Risk of Noncardia Gastric Cancer[J]. Cancer Research on Prevention and Treatment, 2015, 42(05): 470-473. DOI: 10.3971/j.issn.1000-8578.2015.05.010
shu

Single Nucleotide Polymorphism(SNP) in COX-2 Gene are Associated with Risk of Noncardia Gastric Cancer

  • 1. School of Medical Technology, Baotou Medical College, Baotou 014060, China; 2. Department of Laboratory, The First Affiliated Hospital of Baotou Medical College, Baotou 014060, China; 3. Department of Sports Rehabilitation, Baotou Medical College, Baotou 014060, China; 4. Department of Laboratory, The Third Worker Hospital of BAOGANG Group, Baotou 014060, China; 5. School of Basic Medicine, Baotou Medical College, Baotou 014060, China

More Information
  • Received Date: July 22, 2014
  • Revised Date: November 18, 2014
    Graphical Abstract
    • Abstract
  • Objective To investigate the relationship between single nucleotide polymorphism(SNP), rs689466, rs5275, rs4648308, in COX-2 gene and the risk of non-cardia gastric cancer. Methods Three tested SNPs were genotyped by TaqMan method among 288 patients with non-cardia gastric cancer and 281 normal controls. Haplotype was constructed by Haploview software. Odds ratio(OR) and 95% confidence intervals (95%CI) were measured by Logistic regression analysis to evaluate the correlations of the alleles, genotypes, and haplotypes with the susceptibility to non-cardia gastric cancer. Results SNP rs5275 C allele and rs4648308 A allele were significantly associated with an increased risk of non-cardia gastric cancer. And rs5275 CT, CC genotypes and rs4648308 GA genotype were also significantly associated with an increased risk of non-cardia gastric cancer (rs5275: CT vs. TT: OR=1.458, 95% CI: 1.015-2.096); CC vs. TT: OR=3.704, 95%CI: 1.184-11.59; rs4648308: GA vs. GG: OR=3.387, 95%CI:1.953-5.872). Furthermore, haplotype ACA was significantly associated with a higher risk of non-cardia gastric cancer, compared with GTG haplotype (OR=3.198, 95%CI: 1.854-5.516). Conclusion SNP rs5275 and rs4648308 in COX-2 gene are associated with the risk of non-cardia gastric cancer.
    • FullText(HTML)
    • References (21)
  • [1]
    Kim J, Cho YA, Choi IJ, et al. Effects of polymorphisms of innate immunity genes and environmental factors on the risk of noncardia gastric cancer[J]. Cancer Res Treat, 2013, 45(4): 31 3-24.
    [2]
    International Agency for Research on cancer. Schistosomes, liver flukes and Helicobacter pylori. IARC monographs on the evaluation of carcinogenic risks to human[J]. IARC Monogr Eval Carcinog Risks Hum, 1994, 61: 1-241.
    [3]
    Cao p, McClain MS, Forsyth MH, et al. Extracellular release of antigenic protein by Helicobacter Pylori[J]. Infect Immun, 1998, 66 (6): 2984-6.
    [4]
    Laz?r D, T?ban S, Ardeleanu C, et al. Immunohistochemical expression of the cyclooxygenase-2 (COX-2) in gastric cancer. The correlations with the tumor angiogenesis and patients’ survival[J]. Rom J Morphol Embryol, 2008, 49(3): 371-9.
    [5]
    de Melo CF, Gigek CO, da Silva JN, et al. Association of COX2 gene hypomethylation with intestinal type gastric cancer in samples of patients from northern Brazil[J]. Tumour Biol, 2014, 35 (2): 1107-11.
    [6]
    Uefuji K, Ichikura T, Mochizuki H. Cyclooxygenase-2 expression is related to prostaglandin biosynthesis and angiogenesis in human gastric cancer[J]. Clin Cancer Res, 2000, 6(1): 135-8.
    [7]
    Leung WK, To KF, Go MY, et al. Cyclooxygenase-2 up regulates vascular endothelial growth factor expression and angiogenesis in human gastric carcinoma[J]. Int J Oncol，2003, 23(5): 1317-22.
    [8]
    Zhang Z, Liu R, Yang ZH, et al. Cyclooxygenase 2 genetic variant interacting with tobacco smoking and the risk of lung cancer[J]. Zhonghua Yu Fang Yi Xue Za Zhi, 2013, 47(8): 736-40. [张志, 刘 睿, 杨照环, 等. 环氧化酶2遗传变异与吸烟交互作者影响肺癌 易感性[J]. 中华预防医学杂志, 2013, 47(8): 736-40.]
    [9]
    Wu HC, Chang CH, Ke HL, et al. Association of Cyclooxygenase 2 polymorphic genotypes with prostate cancer in taiwan[J]. Anticaner Res, 2011, 31(1): 221-5.
    [10]
    Piranda DN, Festa-Vasconcellos JS, Amaral LM, et al. Polymorphisms in regulatory regions of cyclooxygenase-2 gene and breast cancer risk in Brazilians: a case-control study[J]. BMC Cancer, 2010, 10: 613.
    [11]
    Ashktorab H, Tsang S, Luke B, et al. Protective effect of Cox-2 allelic variants on risk of colorectal adenoma development in African Americans[J]. Anticancer Res, 2008, 28(5B): 3119-23.
    [12]
    Zhu KX, Li YM, Li X, et al. Association of COX-2 genetic polymorphisms and H. pylori infection with gastric cancer in high-incidence Hexi area of Gansu Province in China[J]. Shi Jie Hua Ren Xia Hua Za Zhi, 2008, 16(21): 2364-70. [朱克祥, 李玉 民, 李汛, 等. COX-2基因多态性及Hpylori感染与胃癌高发区甘 肃河西地区胃癌的相关性[J]. 世界华人消化杂志, 2008, 16(21): 23 64-70.]
    [13]
    Kosaka T, Miyata A, Ihara H, et al. Characterization of the human gene(PTGS2) encoding prostaglandin-endoperoxide synthase 2[J]. Eur J Biochem, 1994, 221(3): 889-97.
    [14]
    Zhang X, MiaoX, Tan W, et al. Indentication of functional genetic xariants in cyclooxygenase-2 and their association with risk of esophageal cancer[J]. Gastroenterology, 2005, 129(2): 565-76.
    [15]
    Potter JD, Ulrich CM. COX-2 and gastric cancer: More on Inflammation and Neoplasia[J]. Gastroenterology, 2006, 130(7): 21 98-200.
    [16]
    Dixon DA, Balch GC, Kedersha N, et al. Regulation of cyclooxygenase-2 expression by the translational silencer TIA-1[J]. J Exp Med, 2003, 198(3): 475-81.
    [17]
    Mukhopadhyay D, Houchen CW, Kennedy S, et al. Coupled mRNA stabilization and translational silencing of cyclooxygenase-2 by a novel RNA binding protein, CUGBP2[J]. Mol Cell, 2003,11(1): 11 3-26.
    [18]
    Langsenlehner U, Yazdani-Biuki B, Eder T, et al. The cyclooxygenase-2 (PTGS2) 8473T>C polymorphism is associated with breast cancer risk[J]. Clin Cancer Res, 2006, 12(4): 1392-4.
    [19]
    Campa D, Zienolddiny S, Maggini V, et al. Association of a common polymorphism in the cyclooxygenase 2 gene with risk of non-small cell lung cancer[J]. Carcinogenesis, 2004, 25(2): 229-35.
    [20]
    Hu Z, Miao X, Ma H, Wang X, et al. A common polymorphism in the 3’UTR of cyclooxygenase 2/prostaglandin synthase 2 gene and risk of lung cancer in a Chinese population[J]. Lung Cancer, 20 05, 48(1): 11-7.
    [21]
    Hou L, Grillo P, Zhu ZZ, et al. COX1 and COX2 polymorphisms and gastric cancer risk in a polish population[J]. Anticancer Res, 20 07, 27(6C): 4243-7.
    • Related Articles

Catalog

    Get Citation
    PDF
    XML
    Article views (1205) PDF downloads (470) Cited by()
    Turn off MathJax
    Article Contents
    Abstract
    References

    Download Center

    Links

    Contact Us

    Address：116 Zhuodaoquan South Road,
    Hongshan District, Wuhan（430079）

    Tel：027－87670126

    Email：zlfzyjzz@vip.163.com

    This work is licensed under a Creative Commons Attribution 3.0 License.

    Email Alert RSS
    Total visits： Visits today：

    Copyright © Editorial Department of Cancer Prevention Research 鄂公网安备 42011102005013号 鄂ICP备2022015867号

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return