Expression of CXCR5, CXCL13, MMP-12 and MMP-13 in Colorectal Cancer and Their Significance

QI Xiaowei; JIN Linfang; PU Yong; FENG Jingjie; LIU Yankui; HUA Dong

doi:10.3971/j.issn.1000-8578.2015.02.013

Cancer Research on Prevention and Treatment > 2015 > 42(02): 159-163. > DOI: 10.3971/j.issn.1000-8578.2015.02.013

QI Xiaowei, JIN Linfang, PU Yong, FENG Jingjie, LIU Yankui, HUA Dong. Expression of CXCR5, CXCL13, MMP-12 and MMP-13 in Colorectal Cancer and Their Significance[J]. Cancer Research on Prevention and Treatment, 2015, 42(02): 159-163. DOI: 10.3971/j.issn.1000-8578.2015.02.013

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Expression of CXCR5, CXCL13, MMP-12 and MMP-13 in Colorectal Cancer and Their Significance

1. Department of Pathology, Wuxi No.4 Hospital, Wuxi 214062, China; 2. Department of Oncology, Wu Xi No.4 Hospital, Wuxi 214062, China

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Received Date: October 07, 2013
Revised Date: August 06, 2014

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Abstract

Abstract

Objective To investigate the expression of CXCR5, CXCL13, MMP-12 and MMP-13, and to explore their relationship with clinicopathologic features and prognosis of colorectal carcinoma. Methods The immunohistochemistry staining method was used to detect the expression of CXCR5, CXCL13, MMP-12 and MMP-13 protein in 236 paired specimens of colorectal cancer and normal tissues and 62 cases of colorectal adenoma. Results The positive rates of CXCR5, CXCL13, MMP-12 and MMP-13 were 43.6%, 41.5%, 83.5% and 80.5% in colorectal carcinoma tissues, respectively, which were much higher than those in incisal edge normal intestinal mucosa tissues (4.2%, 5.5%, 11.9% and 13.1%) and those in colorectal adenomas tissues(24.2%, 17.7%, 69.4% and 64.5%) (P<0.05). The expression of CXCR5, CXCL13, MMP-12 and MMP-13 were positively correlated with lymph node metastasis, distant metastasis, TNM stage and relapse(P<0.05). Additionally, CXCL13 positive staining was correlated with poor differentiation(P<0.05). CXCR5 expression was significantly correlated with CXCL13 expression(P<0.05). The expression of CXCR5 and CXCL13 were positively correlated with MMP-12 and MMP-13, respectively (P<0.05). Conclusion The expression of CXCR5，CXCL13，MMP-12 and MMP-13 may play a crucial role in the carcinogenesis, development, metastasis and relapse of colorectal cancer. They could be used as prognostic markers of colorectal cancer in clinical practice.
- CXCR5,
- CXCL13,
- Matrix metalloproteinase-12(MMP-12),
- MMP-13,
- Colorectal cancer,
- Metastasis

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