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WEI Wu, MA Liang, XU Yanjun, WANG Yeyu, LI Dan, JI Aifang. RFT2 Functional SNP Influences Hereditary Susceptibility to Esophageal Squamous Cell Carcinoma[J]. Cancer Research on Prevention and Treatment, 2014, 41(12): 1348-1351. DOI: 10.3971/j.issn.1000-8578.2014.12.021
Citation: WEI Wu, MA Liang, XU Yanjun, WANG Yeyu, LI Dan, JI Aifang. RFT2 Functional SNP Influences Hereditary Susceptibility to Esophageal Squamous Cell Carcinoma[J]. Cancer Research on Prevention and Treatment, 2014, 41(12): 1348-1351. DOI: 10.3971/j.issn.1000-8578.2014.12.021
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RFT2 Functional SNP Influences Hereditary Susceptibility to Esophageal Squamous Cell Carcinoma

  • 1.Central Laboratory, Heping Hospital Affiliated to Changzhi Medical University, Changzhi 046000, China, 2. Department of Oncological Surgery, Heping Hospital Affiliated to Changzhi Medical University, Changzhi 046000, China

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  • Received Date: January 17, 2014
  • Revised Date: September 02, 2014
    Graphical Abstract
    • Abstract
  • Objective To explore the association of RFT2 functional SNP1172C>T and hereditary susceptibility to esophageal squamous cell carcinoma(ESCC). Methods Whole blood genomic DNA were extracted from 240 ESCC patients and 198 healthy people by paramagnetic particle method. RFT2 SNP 1172C>T was determined by sequencing after DNA purification and amplification. The frequency and its correlation with susceptibility to ESCC were then analyzed. Results Overall genotype frequencies of the RFT2 SNP1172C>T in ESCC patients were significantly different from those in healthy controls(χ2=13.10, P=0.001) For 1172C>T, C/T and T/T genotype did not show a relationship with the risk of ESCC, compared with C/C genotype(OR=0.66, 95%CI:0.41-1.05). Conclusion There is a close relationship between SNP1172C>T in RFT2 and hereditary susceptibility to ESCC.
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    • References (11)
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