Expression of Metastasis Suppressor Gene KiSS-1 in Esophageal Squamous Cancer and Its Clinical Significance

YAN Baoguo; DONG Xiaochuan; XIANG Zhengkai

doi:10.3971/j.issn.1000-8578.2014.09.008

Cancer Research on Prevention and Treatment > 2014 > 41(09): 990-992. > DOI: 10.3971/j.issn.1000-8578.2014.09.008

YAN Baoguo, DONG Xiaochuan, XIANG Zhengkai. Expression of Metastasis Suppressor Gene KiSS-1 in Esophageal Squamous Cancer and Its Clinical Significance[J]. Cancer Research on Prevention and Treatment, 2014, 41(09): 990-992. DOI: 10.3971/j.issn.1000-8578.2014.09.008

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Expression of Metastasis Suppressor Gene KiSS-1 in Esophageal Squamous Cancer and Its Clinical Significance

1.Department of Thoracic and Bone-soft Tissue Surgery, Hubei Cancer Hospital, Wuhan 430022,China;2.Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

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Abstract

Abstract

Objective To investigate the expression of metastasis suppressor gene KiSS-1 in esophageal squamous cell carcinoma (ESCC) and its clinical significance. Methods Expression of KiSS-1 in 65 pairs of ESCC and adjacent normal tissues were detected by real-time quantitative RT-PCR assay, and its clinical relevance with clinicopathologic parameters was evaluated. Results KiSS-1 expression in ESCC tissues was significantly lower than those in adjacent normal tissues (P=0.017). The deficient KiSS-1 expression in ESCC tissues was correlated with lymph node metastasis but not correlated with tumor size, histological type, degree of tumor invasion or invasion to adventitia (P=0.480, P=0.827, P=0.823). In addition, the ESCC patients with deficient KiSS-1 expression had significantly poorer overall survival (P=0.009). Conclusion Deficient KiSS-1 expression may be an important biomarker for detecting lymph node metastasis in ESCC, and KiSS-1 might be a potent prognostic marker for ESCC patients.
- Esophageal squamous cell carcinoma(ESCC),
- KiSS-1,
- Metastasis,
- Prognosis

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