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YAN Baoguo, DONG Xiaochuan, XIANG Zhengkai. Expression of Metastasis Suppressor Gene KiSS-1 in Esophageal Squamous Cancer and Its Clinical Significance[J]. Cancer Research on Prevention and Treatment, 2014, 41(09): 990-992. DOI: 10.3971/j.issn.1000-8578.2014.09.008
Citation: YAN Baoguo, DONG Xiaochuan, XIANG Zhengkai. Expression of Metastasis Suppressor Gene KiSS-1 in Esophageal Squamous Cancer and Its Clinical Significance[J]. Cancer Research on Prevention and Treatment, 2014, 41(09): 990-992. DOI: 10.3971/j.issn.1000-8578.2014.09.008

Expression of Metastasis Suppressor Gene KiSS-1 in Esophageal Squamous Cancer and Its Clinical Significance

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  • Objective To investigate the expression of metastasis suppressor gene KiSS-1 in esophageal squamous cell carcinoma (ESCC) and its clinical significance. Methods Expression of KiSS-1 in 65 pairs of ESCC and adjacent normal tissues were detected by real-time quantitative RT-PCR assay, and its clinical relevance with clinicopathologic parameters was evaluated. Results KiSS-1 expression in ESCC tissues was significantly lower than those in adjacent normal tissues (P=0.017). The deficient KiSS-1 expression in ESCC tissues was correlated with lymph node metastasis but not correlated with tumor size, histological type, degree of tumor invasion or invasion to adventitia (P=0.480, P=0.827, P=0.823). In addition, the ESCC patients with deficient KiSS-1 expression had significantly poorer overall survival (P=0.009). Conclusion Deficient KiSS-1 expression may be an important biomarker for detecting lymph node metastasis in ESCC, and KiSS-1 might be a potent prognostic marker for ESCC patients.
  • [1]
    Tachibana M, Kinugasa S, Dhar DK, et al. Prognostic factors in T1 and T2 squamous cell carcinoma of the thoracic esophagus[J]. Arch Surg, 1999, 134(1): 50-4.
    [2]
    Hosch SB, Stoecklein NH, Pichlmeier U, et al. Esophageal cancer: the mode of lymphatic tumor cell spread and its prognostic significance[J]. J Clin Oncol, 2001,19(7): 1970-5.
    [3]
    Sanchez-Carbayo M, Capodieci P, Cordon-Cardo C. Tumor suppressor role of KiSS-1 in bladder cancer: loss of KiSS-1 expression is associated with bladder cancer progression and clinical outcome[J]. Am J Pathol, 2003,162(2): 609-17.
    [4]
    Martin TA, Watkins G, Jiang WG. KiSS-1 expression in human breast cancer[J]. Clin Exp Metastasis, 2005,22(6): 503-11.
    [5]
    Nicolle G, Comperat E, Nicolaïew N, et al. Metastin (KiSS-1) and metastin-coupled receptor (GPR54) expression in transitional cell carcinoma of the bladder[J]. Ann Oncol, 2007,18(3): 605-7.
    [6]
    Ringel MD, Hardy E, Bernet VJ, et al. Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells[J]. J Clin Endocrinol Metab, 2002, 87 (5): 2399.
    [7]
    Cheung IY, Cheung NK. Quantitation of marrow disease in neuroblastoma by real-time reverse transcription-PCR[J]. Clin Cancer Res, 2001,7(6): 1698-705.
    [8]
    Lee JH, Miele ME, Hicks DJ, et al. KiSS-1, a novel human malignant melanoma metastasis-suppressor gene[J]. J Natl Cancer Inst, 1996, 88(23): 1731-7.
    [9]
    Ohtaki T, Shintani Y, Honda S, et al. Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor[J]. Nature, 2001, 411(6837): 613-7.
    [10]
    Shengbing Z, Feng LJ, Bin W, et al. Expression of KiSS-1 gene and its role in invasion and metastasis of human hepatocellular carcinoma[J]. Anat Rec (Hoboken), 2009,292(8): 1128-34.
    [11]
    Lee KH, Kim JR. Kiss-1 suppresses MMP-9 expression by activating p38 MAP kinase in human stomach cancer[J]. Oncol Res, 2009, 18(2-3): 107-16.
    [12]
    Kuohung W, Kaiser UB. GPR54 and KiSS-1: role in the regulation of puberty and reproduction[J]. Rev Endocr Metab Disord, 2006, 7( 4): 257-63.
    [13]
    Ikeguchi M, Yamaguchi K, Kaibara N. Clinical significance of the loss of KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in esophageal squamous cell carcinoma[J]. Clin Cancer Res, 2004, 10(4): 1379-83.
    [14]
    Curtis AE, Murphy KG, Chaudhri OB, et al. Kisspeptin is released from human prostate cancer cell lines but plasma kisspeptin is not elevated in patients with prostate cancer[J]. Oncol Rep, 2010, 23 (6): 1729-34.
    [15]
    Kostadima L, Pentheroudakis G, Pavlidis N. The missing kiss of life: transcriptional activity of the metastasis suppressor gene KiSS1 in early breast cancer[J]. Anticancer Res, 2007, 27(4B): 24 99-504.

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