Research Progression on Angiogenesis Effect and Mechanism of VEGF Promoted by NRP-1

Neuropilin-1(NRP-1), acted as one important member of NRP family,expressed in endothelial cells and certain tumour cells and conducted common receptor of Sema 3A,VEGF,PDGF and TGF. Therefore, it plays an important role in axon growth,angiogenesis and tumor growth. VEGF acts as one important regulating factor in angiogenesis, also played an important role in tumor angiogenesis, growth and development. More and more researches had confi rmed that VEGF could facilitate angiogenesis, tumor growth and development as combined with NRP-1. This article mainly summarizes angiogenesis and mechanism of VEGF promoted by NRP-1.