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ZHANG Qiuming, GONG Wenfeng, HUANG Xiao, WENG Guoqing, ZOU Yongfang, LIAO Jianhong, ZHONG Jianhong. Relationship between 8q24 rs13281615 Gene Polymorphism and Risk of Breast Cancer[J]. Cancer Research on Prevention and Treatment, 2014, 41(04): 400-404. DOI: 10.3971/j.issn.1000-8578.2014.04.026
Citation: ZHANG Qiuming, GONG Wenfeng, HUANG Xiao, WENG Guoqing, ZOU Yongfang, LIAO Jianhong, ZHONG Jianhong. Relationship between 8q24 rs13281615 Gene Polymorphism and Risk of Breast Cancer[J]. Cancer Research on Prevention and Treatment, 2014, 41(04): 400-404. DOI: 10.3971/j.issn.1000-8578.2014.04.026

Relationship between 8q24 rs13281615 Gene Polymorphism and Risk of Breast Cancer

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  • Received Date: January 27, 2013
  • Revised Date: July 04, 2013
  • Objective To explore the association between 8q24 rs13281615 single nucleotide polymorphism and risk of breast cancer (BC). Methods PubMed, EMBASE and the Chinese National Knowledge Infrastructure databases were systematically searched to identify relevant studies. Odds ratios (ORs) with 95% confi dence intervals (CIs) were used to assess the strength of the association. Fixed or random effect models were selected based on the heterogeneity test. Publication bias was estimated using Begg's funnel plots. Results Fourteen studies were included in the meta-analysis, including 44,283 cases (5170 Chinese and 39113 mixed) and 55756 controls (5589 Chinese and 50167 mixed). The 8q24 rs13281615 SNP GG genotype was significantly associated with increasing risk of BC (GG vs. AG+AA, OR=1.13, 95%CI:1.08-1.19, P<0.000), while AA genotype was signifi cantly associated with lower risk of BC (AA vs. AG+GG, OR=0.89, 95%CI:0.84-0.93, P<0.000). Conclusion The 8q24 rs13281615 GG genotype is a risk factor for developing BC, while AA genotype is a protect factor.
  • [1]
    Smigal C, Jemal A, Ward E, et al. Trends in breast cancer by race and ethnicity: update 2006[J]. CA Cancer J Clin, 2006, 56(3): 16 8-83.
    [2]
    Jemal A, Bray F, Center MM, et al.Global cancer statistics[J].CA Cancer J Clin,2011,61(2):69-90.
    [3]
    Parkin DM, Bray F, Ferlay J, et al. Global cancer statistics, 20 02[J]. CA Cancer J Clin, 2005, 55(2): 74-108.
    [4]
    Lichtenstein P, Holm NV, Verkasalo PK, et al. Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland[J]. N Engl J Med, 20 00, 343(2): 78-85.
    [5]
    Hunter DJ, Kraft P, Jacobs KB, et al. A genome-wide association study identifi es alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer[J]. Nat Genet, 2007, 39(7): 870-4.
    [6]
    Easton DF, Pooley KA, Dunning AM, et al. Genome-wide association study identifies novel breast cancer susceptibility loci[J]. Nature, 2007, 447(7148): 1087-93.
    [7]
    Antoniou AC, Sinilnikova OM, McGuffog L, et al. Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers[J]. Hum Mol Genet, 2009, 18 (22): 4442-56.
    [8]
    Campa D, Kaaks R, Le Marchand L, et al. Interactions between genetic variants and breast cancer risk factors in the breast and prostate cancer cohort consortium[J]. J Natl Cancer Inst, 2011, 10 3(16): 1252-63.
    [9]
    Chan M, Ji SM, Liaw CS, et al. Association of common genetic variants with breast cancer risk and clinicopathological characteristics in a Chinese population[J]. Breast Cancer Res Treat, 2012, 136(1): 209-20.
    [10]
    Fletcher O, Johnson N, Gibson L, et al. Association of genetic variants at 8q24 with breast cancer risk[J]. Cancer Epidemiol Biomarkers Prev, 2008, 17(3): 702-5.
    [11]
    Garcia-Closas M, Hall P, Nevanlinna H, et al. Heterogeneity of breast cancer associations with fi ve susceptibility loci by clinical and pathological characteristics[J]. PLoS Genet, 2008, 4(4): e1000054.
    [12]
    Gorodnova TV, Kuligina E, Yanus GA, et al. Distribution of FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 alleles in genetically enriched breast cancer patients versus elderly tumor-free women[J]. Cancer Genet Cytogenet, 2010, 199(1): 69-72.
    [13]
    Harlid S, Ivarsson MI, Butt S, et al. Combined effect of lowpenetrant SNPs on breast cancer risk[J]. Br J Cancer, 2012, 10 6(2): 389-96.
    [14]
    Jiang Y, Han J, Liu J, et al. Risk of genome-wide association study newly identified genetic variants for breast cancer in Chinese women of Heilongjiang Province[J]. Breast Cancer Res Treat, 2011, 128(1): 251-7.
    [15]
    Long J, Shu XO, Cai Q, et al. Evaluation of breast cancer susceptibility loci in Chinese women[J]. Cancer Epidemiol Biomarkers Prev, 2010, 19(9): 2357-65.
    [16]
    McInerney N, Colleran G, Rowan A, et al. Low penetrance breast cancer predisposition SNPs are site specifi c[J]. Breast Cancer Res Treat, 2009, 117(1): 151-9.
    [17]
    Shan J, Mahfoudh W, Dsouza SP, et al. Genome-Wide Association Studies (GWAS) breast cancer susceptibility loci in Arabs: susceptibility and prognostic implications in Tunisians[J]. Breast Cancer Res Treat, 2012, 135(3): 715-24.
    [18]
    Tamimi RM, Lagiou P, Czene K, et al. Birth weight, breast cancer susceptibility loci, and breast cancer risk[J]. Cancer Causes Control, 2010, 21(5): 689-96.
    [19]
    Teraoka SN, Bernstein JL, Reiner AS, et al. Single nucleotide polymorphisms associated with risk for contralateral breast cancer in the Women's Environment, Cancer, and Radiation Epidemiology (WECARE) Study[J]. Breast Cancer Res, 2011, 13 (6): R114.
    [20]
    Li LH, Guo ZJ, Hua D, et al. Association of the 8q24 rs13281615 polymorphisms with breast cancer risk and Clinical and Pathological Characteristics in Chinese Han Women[J]. Zhonghua Jian Yan Yi Xue Za Zhi,2011,34(1): 73-6. [李莉华, 郭子健, 华东 等. 8q24 rs13281615基因多态性与中国汉族女性乳腺癌患病风 险及临床病理特征的关系[J]. 中华检验医学杂志, 2011, 34(1): 73 -6. ]
    [21]
    Saadat M. Paraoxonase 1 genetic polymorphisms and susceptibility to breast cancer: A meta-analysis[J]. Cancer Epidemiol, 2012, 36 (2): e101-3.
    [22]
    Pabalan N, Jarjanazi H, Sung L,et al. Menopausal Status Modifi es Breast Cancer Risk Associated with the Myeloperoxidase (MPO) G463A Polymorphism in Caucasian Women: A Meta-Analysis[J]. PLoS One, 2012, 7(3):e32389.
    [23]
    Walsh T, Casadei S, Coats KH, et al. Spectrum of mutations in BRCA1, BRCA2, CHEK2, and TP53 in families at high risk of breast cancer[J]. JAMA, 2006, 295(12): 1379-88.
    [24]
    Song JY,Zhang LN,Zheng H,et al. Association between a single nucleotide polymorphism in 8q24 rs13281615 and breast cancer risk: a Meta-analysis[J].Zhong Liu,2012,32(1):38-41,64.[宋俊颖, 张丽娜, 郑红, 等. 8q24 rs13281615单核苷酸多态性与乳腺癌发 病风险的Meta分析[J]. 肿瘤, 2012, 32(1): 38-41,64.]
    [25]
    McCracken M, Olsen M, Chen MS Jr, et al. Cancer incidence, mortality, and associated risk factors among Asian Americans of Chinese, Filipino, Vietnamese, Korean, and Japanese ethnicities[J]. CA Cancer J Clin, 2007, 57(4): 190-205.
    [26]
    Ziv E, John EM, Choudhry S, et al. Genetic ancestry and risk factors for breast cancer among Latinas in the San Francisco Bay Area[J]. Cancer Epidemiol Biomarkers Prev, 2006, 15(10): 18 78-85.
    [27]
    Jemal A, Bray F, Center MM, et al. Global cancer statistics[J]. CA Cancer J Clin, 2011, 61(2): 69-90.
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