Relationship between 8q24 rs13281615 Gene Polymorphism and Risk of Breast Cancer

ZHANG Qiuming; GONG Wenfeng; HUANG Xiao; WENG Guoqing; ZOU Yongfang; LIAO Jianhong; ZHONG Jianhong

doi:10.3971/j.issn.1000-8578.2014.04.026

Cancer Research on Prevention and Treatment > 2014 > 41(04): 400-404. > DOI: 10.3971/j.issn.1000-8578.2014.04.026

ZHANG Qiuming, GONG Wenfeng, HUANG Xiao, WENG Guoqing, ZOU Yongfang, LIAO Jianhong, ZHONG Jianhong. Relationship between 8q24 rs13281615 Gene Polymorphism and Risk of Breast Cancer[J]. Cancer Research on Prevention and Treatment, 2014, 41(04): 400-404. DOI: 10.3971/j.issn.1000-8578.2014.04.026

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Relationship between 8q24 rs13281615 Gene Polymorphism and Risk of Breast Cancer

1.Department of Ward Senior,The Tenth Affiliated Hospital of Guangxi Medical University, Qinzhou535000,China; 2.Department of Surgical Oncology,The Tumor Hospital of Guangxi Medical University; 3.Department of Medical Oncology,The Tenth Affiliated Hospital of Guangxi Medical University

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Received Date: January 27, 2013
Revised Date: July 04, 2013

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Abstract

Abstract

Objective To explore the association between 8q24 rs13281615 single nucleotide polymorphism and risk of breast cancer (BC). Methods PubMed, EMBASE and the Chinese National Knowledge Infrastructure databases were systematically searched to identify relevant studies. Odds ratios (ORs) with 95% confi dence intervals (CIs) were used to assess the strength of the association. Fixed or random effect models were selected based on the heterogeneity test. Publication bias was estimated using Begg's funnel plots. Results Fourteen studies were included in the meta-analysis, including 44,283 cases (5170 Chinese and 39113 mixed) and 55756 controls (5589 Chinese and 50167 mixed). The 8q24 rs13281615 SNP GG genotype was significantly associated with increasing risk of BC (GG vs. AG+AA, OR=1.13, 95%CI:1.08-1.19, P<0.000), while AA genotype was signifi cantly associated with lower risk of BC (AA vs. AG+GG, OR=0.89, 95%CI:0.84-0.93, P<0.000). Conclusion The 8q24 rs13281615 GG genotype is a risk factor for developing BC, while AA genotype is a protect factor.
- rs13281615,
- Gene polymorphism,
- Breast cancer,
- Meta analysis

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