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CAO Mengran, HUA Haiqing, QIN Shukui. Protective Effects of Monosialoganglioside on Oxaliplatin-induced Chronic Sensory Neurotoxicity[J]. Cancer Research on Prevention and Treatment, 2014, 41(04): 387-390. DOI: 10.3971/j.issn.1000-8578.2014.04.023
Citation: CAO Mengran, HUA Haiqing, QIN Shukui. Protective Effects of Monosialoganglioside on Oxaliplatin-induced Chronic Sensory Neurotoxicity[J]. Cancer Research on Prevention and Treatment, 2014, 41(04): 387-390. DOI: 10.3971/j.issn.1000-8578.2014.04.023

Protective Effects of Monosialoganglioside on Oxaliplatin-induced Chronic Sensory Neurotoxicity

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  • Received Date: December 26, 2012
  • Revised Date: April 09, 2013
  • Objective To observe the protective effects of monosialoganglioside on oxaliplatin-induced sensory neurotoxicity. Methods Sixty-eight patients receiving oxaliplatin-based chemotherapy were randomly divided into treatment group(n=38, monosialoganglioside, 40 mg/d, 3d) and control group(n=30, fursultiamine, 50 mg, orally bid, three times a day, continuous medication) to prevent oxaliplatin-induced sensory neurotoxicity. The acute and cumulative sensory neurotoxicity, chemotherapeutic effect and adverse reactions in two groups after chemotherapy were assessed. Results The incidence of acute sensory neurotoxicity in monosialoganglioside group was significantly lower than that in control group(5.3% vs. 26.7%, P=0.013). The incidence of cumulative sensory neurotoxicity in control group was 63.3%(19/30), with grade 1-2 in 15 cases, grade 3 in 3 cases and grade 4 in 1 case, signifi cantly higher than that 15.8%(6/38) in monosialoganglioside group, with grade 1-2 in 6 cases. There was no statistically signifi cant difference in chemotherapy-induced adverse reaction, ORR, DCR or mPFS between both groups. Conclusion Monosialoganglioside is an effective neuroprotectant against oxaliplatin-induced sensory neurotoxicity without infl uencing in chemotherapeutic effi cacy or chemotherapy-induced adverse reaction.
  • [1]
    Cassidy J, Misset JL.Oxaliplatin related side effects: Characteristics and management[J]. Semin Oncol, 2002, 29(5 Suppl 15):11-20.
    [2]
    Lévi F, Misset JL, Brienza S, et al. A chronopharmacologic phase II clinical trial with 5-fluorouracil, folinic acid, and oxaliplatin using an ambulatory multichannel programmable pump. High antitumor effectiveness against metastatic colorectal cancer[J]. Cancer, 1992, 69(4):893-900.
    [3]
    Gamelin E,Gamelin L,Bassi L,et al. Clinical aspects and molecular basis of oxaliplatin neurotoxicity: current management and development of preventive measures[J]. Semin Oncol, 2002, 29(5 Suppl 15):21-33.
    [4]
    Lehky TJ, Leonard GD, Wilson RH, et al. Oxaliplatin-induced neurotoxicity: acute hyperexcitability and chronic neuropathy[J]. Muscle Nerce, 2004, 29(3):387-92.
    [5]
    Cavaletti G, Tredici G, Petruccioli MG, et al. Effects of different schedules of oxaliplatin treatment on the peripheral nervous system of rat[J]. Eur J Cancer, 2001, 37(18):2457-63.
    [6]
    Cavaletti G, Petruccioli MG, Marmiroli P, et al. Circulating nerve growth factor level changes during oxaliplatin treatment-induced neurotoxicity in the rat[J].Anticancer Res, 2002,22(6C):4199-204.
    [7]
    De Santis S, Pace A, Bove L, et al. Patients treated with antitumor drugs displaying neurological defi cits are characerized by a low circulating level of nerve growth factor[J]. Clin Cancer Res, 2000, 6( 1):90-5.
    [8]
    Hochster HS,Grothey A,Childs BH. Use of calcium and magnesium salts to reduce oxaliplatin-related neurotoxicity[J]. J Clin Oncol, 20 07, 25(25): 4028-9.
    [9]
    Yin XH, Sun LM, Deng SH. Mechanism of action and clinical research progress of monosialoganglioside[J].Zhongguo Ji Ceng Yi Yao,2006,13(9):1567-9.[尹晓慧, 孙立明, 邓树海. 神经节苷脂 作用机制及临床研究进展[J]. 中国基层医药,2006,13(9):1567-9.]
    [10]
    Ning N, Chen NH. Progress in the research of Ganglioside’ s biological activities[J]. Sheng Li Ke Xue Jin Zhan, 2009, 40 (1):24.[宁娜,陈乃宏. 神经节苷脂的生物学活性[J]. 生理科 学进展,2009,40(1):24.]
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