Clinicopathologic Analysis of 3 Cases with Langerhans Cell Histiocytosis of Bone

Objective To investigate the Clinicopathologic features, immunophenotype, differential diagnosis and prognosis of Langerhans cell histiocytosis of bone. Methods Three cases of LCH were analyzed by clinical data, HE staining and immunohistochemistry of EnVision technique, and review the related literatures. Results Three cases ranged from 7 to 12 years were 2 males and 1 female (mean 8.7 years). The sites of 3 cases was localized in tibia, humerus and frontal bone. Microscopically, LCH was characterized by abnormal proliferative of pathological Langerhans cell????with eosinophils, lymphocyte, neutrophils and some multinucleated giant cell. Immunohistochemically, langerhans cells were positive for CD1a and S100 protein in all cases. Conclusion The most patients of Bone LCH had a good prognosis, which depended on lesions involving the range, with or without organ dysfunction and age．