Relationship between Expression of p57^KIP2 and cyclin E Proteins and Clinicopathologic Features in Endometrial Adenocarcinoma Tissues

Objective To research the relationship between the expressions of p57^KIP2 and cyclin E proteins and clinical pathological features in endometrial adenocarcinoma. Methods The expressions of p57^KIP2 and cyclin E proteins in 100 cases of endometrial adenocarcinoma(EA),20 cases of normal endometrium tissues，20 cases of endometrial proliferative lesions and 20 cases of endometrial intraepithelial neoplasia(EIN) were detected respectively by immunohistochemical Elivision methods. Results The positive expression of p57^KIP2 protein was the highest in EIN,and lowest in proliferative lesions,and slightly higher in normal endometrial tissue than that in EA. But only between EIN and proliferative lesions,the difference of p57^KIP2 was significant(P≤0.05).The positive expression of cyclin E protein was the lowest in normal endometrial tissue,and gradually increased in proliferative lesions and EIN,and the highest in EA (P≤0.05,P<0.01).In EA,the expressions of p57^KIP2 and cyclin E proteins were associated with histological grading,depth of myometrial invasion and surgical stages (P≤0.05,P<0.01).The expression of cyclin E protein was associated with pelvic lymph node metastasis (P<0.01). Both protein expressions were unrelated to age (P>0.05).There was negative relationship between p57^KIP2 and cyclin E protein (P<0.01). Conclusion p57^KIP2 and cyclin E might be involved in the development and progression of endometrial carcinoma and predict the biological behavior of carcinoma.