Relationship and Expression of Leptin，Estrogen and Estrogen Receptor in Lung Cancer Tissue

Objective To study the expressions of Leptin，Estrogen and Estrogen receptor(ER) in lung adenocarcinoma and squamous cell carcinoma. Methods The expressions of Leptin，Estrogen and Estrogen receptor were detected in 41 cases of lung adenocarcinoma and 32 cases of squamous cell carcinoma tissues by immunohistochemistry. Results In 41 cases of lung adenocarcinoma，the expression rates of Leptin, Estrogen and Estrogen receptor (ER) were 78.05%(32/41),36.59%(15/41) and 60.98%(25/41),respectively, and higher than those in 32 lung squamous cell carcinoma 56.25%(18/32),15.63%(5/32) and 37.5% (12/32), respectively （P<0.05）. In 27 female cases with adenocarcinoma，the expression rate of ER was increased, compared 14 male cases with adenocarcinoma, 74.07%(20/27) vs.35.71% (5/14) （P<0.05）. However, the expressions of Leptin, Estrogen had no relations to gender, histology types,clinical stage (P>0.05). Conclusion Leptin,Estrogen and ER were highly expressed in lung adenocarcinoma. ER was highly expressed in female adenocarcinoma. The expressions of Leptin,Estrogen and Estrogen receptor(ER) may associated with the carcinogenesis and development of lung adenocarcinoma.