Association of Vascular Endothelial Growth Factor Gene+936C/T Polymorphisms with Breast Cancer: A Meta-analysis

Objective To explore the relationship between the polymorphism of VEGF and genetic susceptibility of breast cancer. Methods References were retrieved in PubMed, EMBASE, the Cochrane library, Chinese Biological Medicine Disk.Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this association. All analyses were conducted in Stata12.0. Results A total of 10 case-control studies with 17 713 subjects on VEGF+936C/T were included in this Meta- analysis, significant decreased risks were found in allele model T vs. C: OR(95%CI)=0.90(0.81-0.99); co-dominant model CT vs. CC：OR (95%CI )=0.88(0.78-0.90), TT vs. CC: OR(95%CI)=0.91(0.74-1.12); dominant model TT+CT vs. CC: OR(95%CI )=0.88 (0.78-0.99);recessive model TT vs. CT+CC: OR(95%CI)=0.93 (0.76~1.15) . Conclusion +936C/T polymorphism of the VEGF gene is associated with breast cancer, T allele may be a protective factor.