Expression of ercc1 and rrm1 Genes in Invasive Non-hodgkin′s Lymphoma and Clinical Significance

Objective To investigate the relations between the expression of the ercc1 and rrm1 genes in invasive non-hodgkin's lymphoma and the clinical features and prognosis. Methods The Taqman RT - PCR method was used to detect the expressions of rrm1 and ercc1 genes existed in the invasive non-hodgkin's lymphoma from 65 cases patients' tumor tissues. Then the χ² test, Fisher 's precise inspection, Kaplan-Meier survival analysis methods were performed to analyze the relationships between the clinical features of patients，PFS and OS. Results （1）The high expression of ercc1 gene was only appeared in the invasive non-hodgkin's lymphoma patients, the incidence was 18%, mainly expressed in T lymphoblastoid cells and peripheral T cells; the high expression of rrm1 gene was appeared both in the aggressive B-and T-cell lymphoma ，and much higher in the B cells （8/31 vs.2/33，P=0.044）.（2）The high expression of ercc 1 gene and rrm 1 gene in the invasive non-hodgkin's lymphoma patients were concerned with shorter progression-free survival (χ²=4.323，P=0.038) and overall survival time (χ²=5.728，P=0.017). Conclusion （1）This study prompts that the aggressive lymphoma is sensitive to platinum and gemcitabine. （2）The expressions of ercc1 and rrm1 are significant to the aggressive non-Hodgkin's lymphoma's prognosis and forecast.