Clinical Significance of microRNA-93 Expression in Gastric Tumor

Objective To investigate the expression of microRNA-93 and analyze their correlation with clinic-pathological features in gastric tumor. Methods The expression levels of microRNA-93 in 60 gastric tumors and their matched non-tumor adjacent tissue specimens were detected using stem-loop real-time reverse transcription-polymerase chain reaction (RT-qPCR), and their correlation with clinic-pathologic features，cancer therapeutics and prognosis of gastric tumor was analyzed. Results Expression levels of microRNA-93 were significantly higher in tumor tissues than that in adjacent normal tissues (P<0.05). The expression of microRNA-93 was associated with TNM stage (P<0.05) and lymphatic metastasis (P<0.05). The high expression of microRNA-93 group was the comparative expression more than 2.0. Multivariate analysis showed the prognosis was statistically correlated with TNM stage，lymphatic metastasis and microRNA-93 expression（P<0.01）.The high expression of microRNA-93 reduced the effect of cancer therapeutics. Conclusion microRNA-93 is highly elevated in gastric cancer, especially in advanced and metastasized gastric cancer, suggesting microRNA-93 plays critical roles in carcinogenesis of gastric cancer. microRNA-93 might play an important role in gastric tumor and function as the potential gene therapy target for this tumor.