Expression and Clinical Significance of Special AT-rich Sequence-binding Protein in Colorectal Carcinoma

ObjectiveTo detect the expression of special AT-rich sequence-binding protein 1(SATB1) and its correlation to the biological behavior in human colorectal carcinoma. Methods SATB1mRNA and protein were detected in 39 cases of colorectal carcinoma and adjacent non-tumorous tissues by reverse transcriptase polymerase chain reaction(RT-PCR)and Immunohistochemistry respectively.The correlations between SATB1 and clinicopathological parameters were analyzed. Results The expression of SATB1 in colorectal carcinoma tissues was significantly higher than that in adjacent non-tumorous tissues(P＜0.05).The positive expression rate of SATB1 was 69.23%(27/39),and positively correlated to tumorous invasion and clinical stages and metastasis.Over expression of SATB1mRNA was more predominant in patients with deeper invasive colorectal carcinoma(P＜0.05)，and the expression of SATB1mRNA was correlated to the clinical stage and metastasis of the tumor. Conclusion SATB1 expression was associated with the development and metastasis of human colorectal carcinoma,and might serve as an important parameter for determining the clinical diagnosis,treatment and prognosis.