Observation of Intervention Effect of Elemene Emulsus Injecta on Thrombophilia Caused by Chemotherapy

Objective (1)In the view of condition of thrombophilia after the improvement of chemotherapy,to manifest the new scientific connotation of the alleviation of the therapeutic principle of activating blood circulation to dissipate blood stasis for toxicity caused by chemotherapy.(2)To provide evidences of experiment of seeking effective,economic and safe antithrombotic medicines from traditional Chinese medicine (TCM) and new methods of the prevention and treatment of condition of thrombophilia caused by chemotherapy from the beginning of the prevention and treatment of condition thrombophilia in Elemene Emulsion Injection. Methods Clinical experimental methods of design including foresight,parallel control and stratified blocked randomization.The clinical research amounts to 60 cases for observation in which 30 cases in treatment group were treated continuously for fourteen days by chemotherapy,taking Jianpiyishen Compound and intravenous infusion of Elemene Emulsion Injection.The 30 patients in control group were treated by chemotherapy and Jianpiyishen Compound.The two groups before and after therapy were carried out the assessment of symptoms of blood stasis syndrome and signs and the related investigation of indicators of condition of thrombophilia,respectively. Results (1)In the control group,the symptoms and signs of blood stasis syndrome of tumor patients after chemotherapy were aggravated than those before chemotherapy,and their indicators of coagulation and fibrinolysis were both raised(P<0.05),and the formation of thrombus was found in one case.(2)In the treatment group,the symptoms and signs of malignant tumor patients after chemotherapy were alleviated and the number of platelets,plateletcrit PCT and fibrinogen all were apparently decreased(P<0.05). Conclusion (1)Chemotherapy is one of important factors causing condition of thrombophilia of tumor.(2)Elemene Emulsion Injection can prevent and cure condition of thrombophilia caused by chemotherapy.