Combined Percutaneous Microwave Coagulation Therapy and S-1 in Treatment of Liver Metastases from Colon Cancer

Objective To evaluate the effect of percutaneous microwave coagulation therapy (PMCT) combined with S-1 in the treatment of liver metastases from colon cancer. Methods From May 2009 to January 2011,56 patients with liver metastases from colon cancer were randomly divided into treatment group (PMCT and S-1) and control group (only PMCT).In the treatment group,S-1 was administered 50 mg/m2/d for 14 consecutive days following a 1-week rest,3 weeks for a cycle.The effects were evaluated after 6 cycles. Results There were 19 (67.85％) CR,7(25％) PR,1 (3.5％) SD in the treatment group,and 10(35.71％) CR,6(21.42％) PR,8 (28.57％) SD in the control group.The overall response rates were 92.85% and 57.14%,respectively.There was significant difference between two groups (P<0.05).Major adverse reactions were myelosuppressive and gastrointestinal toxicities. Conclusion PMCT combined with S-1 shows well tolerance and good effect as a new therapy for patients with liver metastases from colon cancer.