Expression and Significance of MMP-7 and survivin in Gastric Cancer

Objective To investigate the expression and significance of MMP-7 and survivin in gastric cancer.MothodsImmunohistochemical assay was used to detect the expressions of MMP-7 and survivin in 61 gastric carcinoma specimens and 30 gastric mucosa membrane.And the result with consolidation of clinical pathological materials was analyzed. Results Expressions of MMP-7 and survivin were correlated with tumor invasion,lymph node metastasis,TNM staging,tumor differentiation,and five years survival time(P<0.05),and were not positively correlated with age grading，gender，tumor sizes and position (P>0.05). Conclusion Overexpressions of MMP-7 and survivin correlate with occurrence and development of gastric cancer.