Advanced Search
Tao Hua, Kong Cheng, Lu Jincheng. Phase Ⅱ Study of Intensity-Modulated Radiotherapy Combined with 5-Fluorouracil and Nedaplatin Chemotherapy in Recurrent Esophageal Carcinoma after Curative Operation[J]. Cancer Research on Prevention and Treatment, 2012, 39(10): 1261-1264. DOI: 10.3971/j.issn.1000-8578.2012.10.026
Citation: Tao Hua, Kong Cheng, Lu Jincheng. Phase Ⅱ Study of Intensity-Modulated Radiotherapy Combined with 5-Fluorouracil and Nedaplatin Chemotherapy in Recurrent Esophageal Carcinoma after Curative Operation[J]. Cancer Research on Prevention and Treatment, 2012, 39(10): 1261-1264. DOI: 10.3971/j.issn.1000-8578.2012.10.026

Phase Ⅱ Study of Intensity-Modulated Radiotherapy Combined with 5-Fluorouracil and Nedaplatin Chemotherapy in Recurrent Esophageal Carcinoma after Curative Operation

More Information
  • Received Date: November 15, 2011
  • Revised Date: March 27, 2012
  • Objective To analyze the feasibility and safety of postoperative recurrent esophageal carcinoma patients treated by intensity-modulated radiotherapy combined with 5-Fluorouracil(5-Fu) and nedaplatin chemotherapy. Methods Forty-four esophageal carcinoma patients suffered recurrence after their definitive resection in our department from June 2009 to June 2010.Intensity-modulated radiotherapy combined with 5-Fu and nedaplatin chemotherapy was performed in the patients(gross tumor volume,GTV) of IMRT was prescribed to 60 Gy/30f,2.0 Gy/f and 5-Fu and nedaplatin concurrent chemotherapy was used by 5-Fu 750 mg/(m2·d),d1~5,nedaplatin 80 mg/(m2·d),d1 at week 1 and week 4.The primary endpoint was 1-year survival rate and the second endpoint was toxicity related to the treatment. Results The overall response rate (CR+PR) was 86%(38/44).1- and 2-year overall survival rate was 72.7% and 60%,respectively.1- and 2-year progression-free survival rate was 63.6% and 36.6%,respectively.Univariate analysis outcome showed that only recurrent site was related with prognosis (χ2=22.848,P=0.000).All the patients undergone this treatment smoothly.Grade Ⅰ,Ⅱ and Ⅲ leukocytopenia was observed in 16% (7/44),50% (22/44),and 34% (15/44) patients,respectively.Grade I,and II digestive tract toxicity was observed in 45% (20/44),55% (24/44) patients,respectively.Grade Ⅰ,and Ⅱ liver/renal toxicity was observed in 77% (34/44),and 23% (10/44) patients,respectively.Over grade 3 digestive tract and liver/renal toxicity were not found.All the toxicities were gone after corresponding therapy. Conclusion Concurrent chemotherapy with 5-Fu and nedaplatin plus intensity-modulated radiotherapy is an effective and feasible regimen and would be considered as a better option for postoperative recurrent esophageal carcinoma patients,which could be deserved to be applied to phase Ⅲ clinical trial.
  • [1]
    Jemal A,Bray F,Center MM,et al.Global Cancer Statistics [J].CA Cancer J Clin,2011,61(2):69-90.
    [2]
    Jemal A,Siegel R,Ward E,et al.Cancer statistics,2009[J].CA Cancer J Clin,2009,59(4):225-49.
    [3]
    Enzinger PC,Mayer RJ.Esophageal cancer [J].N Engl J Med,2003,349(23):2241-52.
    [4]
    Abate E,DeMeester SR,Zehetner J,et al.Recurrence after esophagectomy for adenocarcinoma:defining optimalfollow-up intervals and testing[J].J Am Coll Surg,2010,210(4):428-35.
    [5]
    Kunisaki C,Makino H,Takagawa R,et al.Surgical outcomes in esophageal cancer patients with tumor recurrenceafter curative esophagectomy [J].J Gastrointest Surg,2008,12(5):802-10.
    [6]
    Wang YX,Zhu SC,Li R,et al.Radiotherapy for postoperative regional recurrence in esophageal carcinoma[J].Zhonghua Fang She Zhong Liu Xue Za Zhi,2005,14(2):86-9.[王玉祥,祝淑钗,李任,等.食管癌术后区域性复发的放疗[J].中华放射肿瘤学杂志,2005,14(2):86-9.]
    [7]
    Zhang JR,Yang J,Lv Y,et al.Effect of radiotherapy on loco-regional recurrence of esophageal carcinoma aftersurgery[J].Zhonghua Fang She Zhong Liu Xue Za Zhi,2010,19(4) :302-5.[张瑾熔,杨蛟,吕茵,等.91例术后局部复发转移食管癌放疗疗效和预后分析[J].中华放射肿瘤学杂志,2010,19(4) :302-5.]
    [8]
    Jin J,Wang LH,Yin WB,et al.Radiotherap for postoperative anastomosis recurrence in esophageal carcinoma[J].Zhonghua Fang She Zhong Liu Xue Za Zhi,2000,9(2):87-9.[金晶,王绿化,殷蔚伯,等.食管癌根治术后吻合口复发的放疗[J].中华放射肿瘤学杂志,2000,9(2):87-9.]
    [9]
    Lu JC,Kong C,Tao H.Radiotherapy with or without concurrent chemotherapy for lymph node recurrence afterradical surgery of thoracic esophageal squamous cell carcinoma[J].Int J Radiat Oncol Biol Phys,2010,78(3):710-4.
    [10]
    Carlisle JG,Quint LE,Francis IR,et al.Recurrent esophageal carcinoma:CT evaluation after esophagectomy [J].Radiology,1993,189(1):271-5.
    [11]
    Nemoto K,Ariga H,Kakuto Y,et al.Radiation therapy for loco-regionally recurrent esophageal cancer aftersurgery [J].Radiother Oncol,2001,61(2):165-8.
    [12]
    Raoul JL,Le Prisé E,Meunier B,et al.Combined radiochemotherapy for postoperative recurrence of oesophagealcancer[J].Gut,1995,37(2):174-6.
    [13]
    Nishimura Y,Koike R,Nakamatsu K,et al.Concurrent chemoradiotherapy with protracted infusion of 5-Fu andCisplatin for postoperative recurrent or residual esophageal cancer[J].Jpn J Clin Oncol,2003,33(7):341-5.
    [14]
    Uchida N,Takeda Y,Hojo K,et al.Sequence-dependent antitumour efficacy of combination chemotherapy ofnedaplatin,a novel platinum complex,with 5-fluorouracil in an in vivo murine tumour model[J].Eur JCancer,1998,34(11):1796-801.
    [15]
    Nemoto K,Matsushita H,Ogawa Y,et al.Radiation therapy combined with cis-diammine-glycolatoplatinum(Nedaplatin) and 5-fluorouracil for untreated and recurrent esophageal cancer[J].Am J Clin Oncol,2003,26(1):46-9.
    [16]
    Jingu K,Nemoto K,Matsushita H,et al.Results of radiation therapy combined with nedaplatin (cis-diammine-glycoplatinum and 5-Fluorouracil for postoperative locoregional recurrent esophageal cancer[J].BMCCancer,2006,6:50.
  • Related Articles

    [1]CAO Wenjing, WANG Yulin, ZHAI Yuqing, ZHANG Zongliang, YUAN Jiangshui, SONG Weiqing. Expression and Clinical Significance of MIS18BP1 in Bladder Cancer Tissues[J]. Cancer Research on Prevention and Treatment, 2024, 51(3): 163-168. DOI: 10.3971/j.issn.1000-8578.2024.23.1041
    [2]ZHANG Yuanyuan, FANG Zhaoqin, LIANG Chao. Screening of Genes Involved in Hepatoma Cells SMMC-7721 Stress Response Induced by Different Stressors[J]. Cancer Research on Prevention and Treatment, 2016, 43(6): 463-467. DOI: 10.3971/j.issn.1000-8578.2016.06.006
    [3]Pei Feng, Zhu Yi. Clinical Significance of Cytokeratin18 Fragments in Diagnosis of Gastric Cancer[J]. Cancer Research on Prevention and Treatment, 2012, 39(04): 439-441. DOI: 10.3971/j.issn.1000-8578.2012.04.018
    [4]YANG Guang-min, LI Shou-qing, MA Yin-fu, WEI Bing-bing, SHI Yang, TAN Yan. Anti-tumor Immunotherapy Effect of Co-expression Genetic Vaccine MAGE-1/IL-18[J]. Cancer Research on Prevention and Treatment, 2010, 37(03): 294-297. DOI: 10.3971/j.issn.1000-8578.2010.03.014
    [5]YANG Sheng, LU Hui-shan, CHEN Xiang-qi, LIN Ting-yan, LI Zhi-ying, KANG Ming-qiang. Effect of IL-18 on Growth and Apoptosis of Lewis Lung Cancer Xenografts in C57BL/6 Mice[J]. Cancer Research on Prevention and Treatment, 2009, 36(07): 563-565. DOI: 10.3971/j.issn.1000-8578.2009.07.007
    [6]ZHAO Hong-xia, WANG Yan-kui, LUO Bing, YIN Guang-jie. Influence of HPV18E6 Small Interfering RNA on p21,VEGF,Bax and Bcl-2 Genes in HeLa Cells[J]. Cancer Research on Prevention and Treatment, 2009, 36(04): 261-264. DOI: 10.3971/j.issn.1000-8578.2009.04.001
    [7]YANG Qin, CHEN Hong-lei, LIU Ming-qiu, FANG Zhong. PCR-SSCP Analysis of FADD Gene Mutation in Non-small Cell Lung Cancer[J]. Cancer Research on Prevention and Treatment, 2006, 33(03): 162-164. DOI: 10.3971/j.issn.1000-8578.442
    [8]GAO Yan-e, YANG Hui-ping, ZHANG Ju, GUO Jin-zhu, LIU Ning-xia, YAN Xiao-jun. Cloning and Sequencing of Human Papillomavirus Type 18 L1 Gene from Cervical Cancer Tissue[J]. Cancer Research on Prevention and Treatment, 2006, 33(03): 159-161. DOI: 10.3971/j.issn.1000-8578.441
    [9]LI Ji-mei, LI Chun-hai, WANG Qin-qin, et al, . Detect ion of MUC1 and GST-P Gene by means of RT-PCR in Axillary Lymph Nodes Taken from Breast Cancer Patients[J]. Cancer Research on Prevention and Treatment, 2001, 28(05): 351-353. DOI: 10.3971/j.issn.1000-8578.1357
    [10]Luo YuanHui, . The Point Mutation of Ras and p53 Genes in Paraffin-embedded Gastric Cancer Tissues by PCR-RFLP Analysis[J]. Cancer Research on Prevention and Treatment, 1995, 22(2): 68-71.

Catalog

    Article views (2305) PDF downloads (659) Cited by()

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return