Advanced Search
Wang Yuxiang, Wang Jun, Zhu Shuchai, Tian Dandan, Lv Dongjie, Wang Yi, Qiao Xueying. Comparison of Prognosis on Esopageal Carcinoma Treated with 3D-CRT and IMRT for Elderly Patients[J]. Cancer Research on Prevention and Treatment, 2012, 39(08): 1008-1013. DOI: 10.3971/j.issn.1000-8578.2012.08.031
Citation: Wang Yuxiang, Wang Jun, Zhu Shuchai, Tian Dandan, Lv Dongjie, Wang Yi, Qiao Xueying. Comparison of Prognosis on Esopageal Carcinoma Treated with 3D-CRT and IMRT for Elderly Patients[J]. Cancer Research on Prevention and Treatment, 2012, 39(08): 1008-1013. DOI: 10.3971/j.issn.1000-8578.2012.08.031
shu

Comparison of Prognosis on Esopageal Carcinoma Treated with 3D-CRT and IMRT for Elderly Patients

  • Department of Radiation Oncology,The Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China

More Information
  • Received Date: October 19, 2011
  • Revised Date: February 01, 2012
    Graphical Abstract
    • Abstract
  • Objective To compare the prognosis of esopageal carcinoma treated with 3-dimensional conformal radiotherapy (3D-CRT) and intensity modulated radiation therapy (IMRT) for patients older than 65 years;and to analysis the related factors affected the prognosis. Methods From January 2001 to December 2008, 105 cases of elderly patients with esopageal carcinoma were treated with 3D-CRT and 48 cases with IMRT. Local control rates, survival rates and its related prognostic factors were evaluated retrospectively with SSPS11.5 software. Results After the treatment with 3D-CRT or IMRT, there was 71 cases in CR, 78 in PR, and 4 in NR. The total efficiency (CR+PR) was 97.4%. The 1 and 3-year over-all survival rate was 70.6% and 34.2%, respectively; and the 1- and 3-year local control rate was 76.2% and 51.1%, respectively. Compared with the clinical data between 3D-CRT and IMRT, there were more patients with metastasis of lymph node, located in middle and lower-thoracic carcinoma, larger diameter of tumor in CT, higher dose of radiotherapy agents, and more patients was combination of chemotherapy in IMRT group (P<0.05). There were no significant differences in the effects of gender, age, T stage and diet before radiotherapy and lesion length bariesophagogram between the two groups (P>0.05). There were no significant differences in the 1- and 3-year survival rate and free-recurrence rate between 3D-CRT and IMRT groups(P>0.05). For all patients, analyzed by univariate analysis, the related factors affected on the prognosis were the different diet, site of lesion, T stage, metastasis of lymph node, lesion length in barium esophagogram and CT image, chemotherapy and the immediate response (P＜0.05). By Cox multivariate analysis, the independent factors affected on the prognosis were chemotherapy and the largest diameter of lesion in CT scanning image (P＜0.05). Conclusion s3D-CRT and IMRT can be considered as effective and feasible approaches for elderly patients with esophageal cancer. Chemotherapy and the largest diameter of lesion in CT scanning image were independent prognostic factors for those patients.
    • FullText(HTML)
    • References (19)
  • [1]
    Xiao ZF,Zhang Z,Zhang HZ,et al.Assessment of tumor dose distribution in three dimensional conformal radiotherapy treatment planning system for esophageal cancer[J].Zhonghua Fang She Zhong Liu Xue Za Zhi,2004,13(4):273-7.[肖泽芬,章众,张宏志,等,用三维治疗计划系统评估食管癌常规放射治疗中肿瘤剂量的分布[J].中华放射肿瘤学杂志,2004,13(4):273-7.]
    [2]
    Wang L,Han CH,Zhu SC,et al.Dosimetry study on conventional and three dimensional conformal radiotherapy for esophageal cancer[J].Zhonghua Fang She Zhong Liu Xue Za Zhi,2006,15(3):176-80.[王澜,韩春,祝淑钗,等.食管癌常规照射与三维适形放疗的剂量学研究[J].中华放射肿瘤学杂志,2006,15(3):176-80.]
    [3]
    Wang SL,Liao Z,Liu H,et al.Intensity-modulated radiation therapy with concurrent chemotherapy for locally advanced cervical and upper thoracic esophageal cancer[J].World J Gastroenterol,2006,12(34):5501-8.
    [4]
    Wang J,Zhu SC,Han C,et al.Comparison of dose distribufions between conformal and intensity.modulated radiotherapy for the upper esophageal carcinoma[J].Zhonghua Fang She Zhong Liu Xue Za Zhi,2008,17(4):275-9.[王军,祝淑钗,韩春,等.胸上段食管癌三维适形和调强放疗剂量学对比研究[J].中华放射肿瘤学杂志,2008,17(4):275-9.]
    [5]
    Zhang ZW,Chen ZJ,Li DR,et al.Dosimetric comparison between intensity-modulated radiotherapy and conformal radiotherapy for upper thoracic esophageal carcinoma[J].Ai Zheng,2009,28(11):1127-31.[张武哲,陈志坚,李德锐,等.胸上段食管癌调强放疗与适形放疗计划的剂量学比较[J].癌症,2009,28(11):1127-31.]
    [6]
    Wang YX,Zhu SC,Li J,et al.Prognostic analysis of three-dimensional conformal radiotherapy (3DCRT) for 209 cases of esopageal carcinoma[J].Zhonghua Fang She Zhong Liu Xue Za Zhi,2010,19(2):101-4.[王玉祥,祝淑钗,李娟,等.209例食管癌三维适形放疗疗效分析[J].中华放射肿瘤学杂志,2010,19(2):101-4.]
    [7]
    Wang J,Han C,Li XN,et al.Short-term efficacy of intensity-modulated radiotherapy on esophageal carcinoma[J].Ai Zheng,2009,28(11):1138-41.[王军,韩春,李晓宁,等.食管癌调强放射治疗初期疗效分析[J].癌症,2009,28(11):1138-41.]
    [8]
    Guo YX.Clinical investigation on the efect and complication of accelerated hyper-fractionation for elderly patients with esophageal carcinoma[J].Zhongguo Zhong Liu Lin Chuang,2006,33(7):386-8.[郭跃信.老年食管癌加速超分割放射治疗的临床探讨[J].中国肿瘤临床,2006,33(7):386-8.]
    [9]
    Li GW,Guo YX.Radiotherapy of esophageal cancer for elder patients more than 80 years[J].Zhonghua Lao Nian Yi Xue Za Zhi,2007,26(3):202-3.[李国文,郭跃信.80岁以上老年人食管癌的放射治疗[J].中华老年医学杂志,2007,26(3):202-3.]
    [10]
    Kosugi S,Sasamoto R,Kanda T,et al.Retrospective review of surgery and definitive chemoradiotherapy in patients with squamous cell carcinoma of the thoracic esophagus aged 75 years or older[J].Jpn J Clin Oncol,2009,39(6):360-6.
    [11]
    Kawashima M,Kagami Y,Toita T,et al.Prospective trail of radiotherapy for patients 80 years of age or older with squamous cell carcinoma of the thoracic esophagus[J].Int J Radiat oncol Biol Phys,2006,64(4):1112-1.
    [12]
    Jiang J,Wang QF,Xiao ZF,et al.Efficacy of three-dimensional conformal radiotherapy for 132 patients with esophageat carcinoma[J].Zhonghua Fang She Zhong Liu Xue Za Zhi,2009,18(1):47-51.[蒋杰,王奇峰,肖泽芬,等.132例食管癌三维适形放疗的疗效分析[J].中华放射肿瘤学杂志,2009,18(1):47-51.]
    [13]
    Wang YX,Zhu SC,Su JW,et al.Prognostic analysis of three-dimensional conformal radiotherapy for elderly patients with esophageal carcinoma[J].Zhonghua Lao Nian Yi Xue Za Zhi,2010,29(2):131-4.[王玉祥,祝淑钗,苏景伟,等.老年人食管癌三维适形放射治疗疗效分析[J].中华老年医学杂志,2010,29(2):131-4.]
    [14]
    Wan X,Qiao XY,Wang YD,et al.Aanlysisi of treatment outcome and prognostic factor with three-dimensional conformal radiotherapy for thoracic esophageal squamous cell carcinoma[J].Zhonghua Fang She Zhong Liu Xue Za Zhi,2011,20(3):202-4.[万欣,乔学英,王雅棣,等.131例食管鳞癌三维适形放疗预后因素分析[J].中华放射肿瘤学杂志,2011,20(3):202-4.]
    [15]
    Chen EC,Liu MZ,Hu YH,et al.A case-contral study on unresectable esophageal carcinoma patients with radiochemotherapy or radiotherapy[J].Zhonghua Fang She Zhong Liu Xue Za Zhi,2007,16(5):416-9.[陈尔成,刘盂忠,胡永红,等.同期放化疗与单纯放疗不能手术食管癌的病例对照研究[J].中华放射肿瘤学杂志,2007,16(5):416-9.]
    [16]
    Nallapareddy S,Wilding GE,Yang G,et al.Chemoradiation is a tolerable therapy for older adults with esophageal cancer[J].Anticancer Res,2005,259(4):3055-60.
    [17]
    Anderson SE,Minsky BD,Bains M,et al.Combined modality chemoradiation in elderly oesophageal cancer patients[J].Br J Cancer,2007,96(12):1823-7.
    [18]
    Zhu SC,Li R,Wang YX,et al.Prognostic factors of locally advanced esophageal carcinoma treated by radiotherapy alone[J].Zhonghua Fang She Zhong Liu Xue Za Zhi,2005,14(4):253-8.[祝淑钗,李任,王玉祥,等.500例中晚期食管癌单纯放疗的多因素分析[J].中华放射肿瘤学杂志,2005,14(4):253-8.]
    [19]
    Chinese expert group of clinical stage for non surgery esophageal cancer.Criterion of clinical stage for non surgery esophageal cancer[J].Zhonghua Fang She Zhong Liu Xue Za Zhi,2010,19(3):179-80.[中国非手术治疗食管癌临床分期专家小组.非手术治疗食管癌的临床分期标准[J].中华放射肿瘤学杂志,2010,19(3):179-80.]
    • Related Articles

  • Related Articles

    [1]LIN Jinlan, GUO Tianxing, PAN Xiaojie, XU Zhenwu. Clinical Observation of Metronomic Oral Vinorelbine Monotherapy as First-line Treatment on Elderly Patients with Advanced Non-small Cell Lung Cancer[J]. Cancer Research on Prevention and Treatment, 2018, 45(11): 909-912. DOI: 10.3971/j.issn.1000-8578.2018.18.0841
    [2]CHEN Pengcheng, MAO Weimin. Clinical Investigation on Qingfei Mixture Combined with Chemotherapy on Middle and Advanced Non-small Cell Lung Cancer[J]. Cancer Research on Prevention and Treatment, 2016, 43(7): 609-615. DOI: 10.3971/j.issn.1000-8578.2016.07.014
    [3]Liu Mingyue, Hou Guiqin, Gao Tianhui, Cui Yao, Li Xiaoyan, Zhou Yun. Efficacy of Pemetrexed Chemotherapy in Advanced Non-small Cell Lung Cancer with EGFR-TKI Resistence[J]. Cancer Research on Prevention and Treatment, 2012, 39(06): 713-715. DOI: 10.3971/j.issn.1000-8578.2012.06.025
    [4]Tong Wanning, Zhang Jun, Zhuo Anshan, Cao Yushu. Clinical Effects of Whole Body Gamma Knife Combined with Pemetrexed Plus Carboplatin on Concurrent Chemoradiotherapy for Locally Advanced Non-small Cell Lung Cancer[J]. Cancer Research on Prevention and Treatment, 2012, 39(01): 81-84. DOI: 10.3971/j.issn.1000-8578.2012.01.021
    [5]WANG Ya-di, HA Min-wen, AN Yu-zhi, WANG Yue, CHENG Jian, LIU Wei. Clinical Observation of Gemcitabine Monotherapy in Treatment of Elder Advanced Non-small Cell Lung Cancer[J]. Cancer Research on Prevention and Treatment, 2011, 38(06): 698-700. DOI: 10.3971/j.issn.1000-8578.2011.06.025
    [6]TAO Dan, LONG Zhi-xiong, WANG Bin, LIU Yan-ping, GAO Xia, HUANG Ya-li, WU Jing, HUANG Hui, WAN Huan. Clinical Effects of Accelerator Linear Plus Gamma Knife Radiotherapy Combined with Concurrent DP Regimen Chemotherapy for Locally Advanced Non-small Cell Lung Cancer[J]. Cancer Research on Prevention and Treatment, 2011, 38(05): 575-578. DOI: 10.3971/j.issn.1000-8578.2011.05.026
    [7]ZHAN Yong-zi, HUANG Chang-jie, HUANG Jian-feng. Clinical Observation of Erlotinib in Treatment of Patients with Non-small Cell Lung Cancer[J]. Cancer Research on Prevention and Treatment, 2010, 37(04): 461-462. DOI: 10.3971/j.issn.1000-8578.2010.04.025
    [8]FU Xiao-min, WANG Jing, ZHANG Hui, BAO Ai-hua. Clinical Research for Docetaxel Plus Cisplatin in Untreated Adwanced Non-small Cell Lung Cancer[J]. Cancer Research on Prevention and Treatment, 2010, 37(02): 205-208. DOI: 10.3971/j.issn.1000-8578.2010.02.022
    [9]LI Hong-mei, GAO Ya-ling. Clinical Comparison of Three Different Chemotherapy Regimens Including Cisplain for Advanced Non-small Cell Lung Cancer[J]. Cancer Research on Prevention and Treatment, 2006, 33(09): 670-672. DOI: 10.3971/j.issn.1000-8578.1314
    [10]PAN Da-chao, XIE ZHong. The clinical study of combination chemotherapy with navelbine and ifosfamide in treating of advanced Non-small cell lung cancer[J]. Cancer Research on Prevention and Treatment, 2002, 29(03): 241-242. DOI: 10.3971/j.issn.1000-8578.3085

Catalog

    Get Citation
    PDF
    XML
    Article views (3142) PDF downloads (617) Cited by()
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    Download Center

    Links

    Contact Us

    Address：116 Zhuodaoquan South Road,
    Hongshan District, Wuhan（430079）

    Tel：027－87670126

    Email：zlfzyjzz@vip.163.com

    This work is licensed under a Creative Commons Attribution 3.0 License.

    Email Alert RSS
    Total visits：12456798 Visits today：5665

    Copyright © Editorial Department of Cancer Prevention Research 鄂公网安备 42011102005013号 鄂ICP备2022015867号

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return