Interactions between IL-1β Gene Polymorphism and Helicobacter Pylori Infection as Well as Relationship of Helicobacter Pylori and Gene with Risk of Gastric Cancer in Han Nationalities in Xinjiang

Objective To evaluate the interactions between IL-1β gene polymorphism and Helicobacter pylori(Hp) as well as the relationship of Hp and IL-1β gene polymorphism with risk of gastric cancer in Han nationalities in Xinjiang. Methods Snapshot method was carried out to analysis the polymorphism of IL-1β gene in 229 cases of gastric cancer and in 256 controls.The assure Hp rapid test was used to investigate the presence of IgG antibodies to Hp. Results It is possible that incidence of gastric cancer in Han population is associated with the genetic polymorphism of IL-1β and Hp infections.In Han populations,interactions between Hp infections and gene showed that:individuals having IL-1β gene at rs3136558 site TT genotype and Hp infections had a 2.25-fold (95% CI：1.37~3.69) increased risk of developing GC compared with those who having CT+CC genotype but no Hp infections. Conclusion The interactions between the genetic polymorphism of IL-1β gene and Hp infections increase the risk of gastric cancer.