Association of Variant Allele of DICER and Decreased Risk of Esophageal Cancer Lymph Node Metastasis

Objective To investigate the relationship between DICER polymorphism and the susceptibility to lymph node metastasis in esophageal cancer in Chinese Han population. Methods Genotypes were determined by matrix-assisted laser desorption /ionization time-of-flight mass spectrometry (MALDI-TOF MS) method in 85 lymph node metastasis positive patients and 270 lymph node metastasis negative patients. Results The DICER rs3742330 A>G genotype frequencies were 31.76%(AA),61.18%(AG),7.06%(GG) in the lymph node positive group and 34.44%(AA),48.15%(AG),17.41%(GG) in the lymph node negative group,respectively.Logistic regression analyses revealed that the risk associated with DICER rs3742330 GG genotype was 0.36 (95%CI=0.15~0.88) which was much lower than DICER rs3742330 AA+AG genotype. Conclusion DICER rs3742330 A>G polymorphism may be a protective factor of lymph node metastasis.