Inhibition of G31P:Chemokine Receptor CXCR1/CXCR2 Antagonist,in Angiogenesis of Human Prostate Cancer Cells in vivo

Objective To investigate the inhibition of G31P on the angiogenesis of the prostate cancer PC-3 cell in vivo. Methods The effect of G31P on angiogenesis of human prostate tumor of nude mice were observed in nude mice by building a human androgen-independent prostate cancer PC-3 (GFP-labeled) orthotopic transplantation tumor cells model. Results The tumor angiogenesis of G31P treated group （1.26±0.46）was significantly reduced （0.49±0.12，P<0.05) compared with the control group.VEGF（P<0.01）and NF-κB（P<0.01）expression of G31P treated groupwas significantly reduced (immunohistochemistry) compared with the control group. Conclusion G31P could inhibit the angiogenesis of the prostate cancer PC-3 cell in vivo.