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Cui Yanhui, Liang Haijun, Zhang Qingqin, Lu Ping, Miao Zhanhui. Radiosensitization Effect of Arsenic Trioxide on Human Esophageal Cancer Cell Line EC-1[J]. Cancer Research on Prevention and Treatment, 2012, 39(06): 667-670. DOI: 10.3971/j.issn.1000-8578.2012.06.013
Citation: Cui Yanhui, Liang Haijun, Zhang Qingqin, Lu Ping, Miao Zhanhui. Radiosensitization Effect of Arsenic Trioxide on Human Esophageal Cancer Cell Line EC-1[J]. Cancer Research on Prevention and Treatment, 2012, 39(06): 667-670. DOI: 10.3971/j.issn.1000-8578.2012.06.013
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Radiosensitization Effect of Arsenic Trioxide on Human Esophageal Cancer Cell Line EC-1

  • 1.Department of Oncology，The First Affiliated Hospital，Xinxiang Medical University，Weihui 453100，China，2.Department of Infection Disease

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  • Received Date: September 07, 2011
  • Revised Date: January 19, 2012
    Graphical Abstract
    • Abstract
  • Objective To explore the radiosensitivity effect and mechanism of action of Arsenic trioxide(Arsenic trioxide ，As2O3) on esophageal carcinoma EC-1 cell line.MethodThe radiosensitivity effect of Arsenic trioxide(As2O3) on esophageal carcinoma EC-1 cell line by fitting the irradiation dose-survival curve using ‘multitarget click mathematical model'.Flow cytometry(FCM) was used to detect the changes of cell apoptosis and cell cycle. Results As2O3 had an obvious radiosensitivity effect on esophageal carcinoma EC-1 cells.After treatment with 3 μmol／L As2O3 for 48 hours，the sensitization enhancement ratio(SER) is 1.285.The G2/M phase ratio is increased while the G0/G1 phase and the S phase ratio decreased after treatment.The apoptotic index was significantly increased(P<0.05),compared with the control group. Conclusion As2O3 has an obvious radiosensitivity effect on esophageal carcinoma EC-1 cells，and the mechanism of action may be related to decreased repair capacity of the EC-1 cells,the cell cycle arresting is G2/M phase,the decreased cell number of G0,G1 and S phase and increased apoptosis.
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    • References (11)
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