Toxic Effect and Long-term Survival of Three Dimensional Conformal High-dose Radiotherapy for Non- small Cell Lung Cancer

Objective To compare the long term survival and side effects of the high-dose radiotherapy with the convention radiotherapy for locally advanced non-small cell lung cancer(NSCLC),and to analysis the prognostic factors. Methods From Jan,2000 to Jan,2004,75 patients underwent high-dose radiotherapy(HRT) and 83 patients received conventional radiotherapy(CRT) in non-small cell lung cancer were analyzed.The clinical evaluation of the patients in the recent 3 months after radiotherapy were carried out according RECIST criteria.The toxicity reaction to the patients were graded.SPSS11.5 software was used for statistical analysis. Results The two groups had the same variable.For all patients,the overall response rate(CR + PR) was 80.4%,and the 1-,3- and 5- year survival rates were 44.9 %,19.0% and 11.7%,respectively.There were no statistics significance between HRT group and CRT group.For all patients,the 1-,3- and 5-years local control rate was 76.8%,48.1% and 40.5%,respectively.There were statistics significance between HRT group and CRT group(χ²=3.80，P=0.041).The multivariate analysis showed that the maximum diameter of tumor,chemotherapy,treatment time and short-term curative effect were independent prognostic factors.Compared HRT group with CRT group,the treatment time was shorter(χ²=3.93，P=0.047),and the short-term curative effect was better(χ²=9.649，P=0.022).But,there were no statistics significance between the two groups in the rate of radiation injury. Conclusion The high-dose radiotherapy has a good long effective in the treatment of NSCLC.The treatment time was shorter and the side effects were not more.