Expression of VEGF-C in Nonmucinous Bronchioalveolar Carcinoma and Pulmonary Adenocarcinoma Tissues

Objective To discuss invasiveness and metastasis of nonmucinous bronchioalveolar carcinoma. Methods Fourty-three cases with nonmucinous bronchioalveolar carcinoma were enrolled in experimental group，control group consisted of 17 cases of mucinous bronchioalveolar carcinoma，22 cases of pulmonary adenocarcinoma and 10 cases of lung tissue adjacent to nonmucinous bronchioalveolar carcinoma.Expression of VEGF-C protein and mRNA were detected using immunohistochemical method and RT-PCR，respectively. Results Positive rate of VEGF-C protein in nonmucinous bronchioalveolar carcinoma was significantly higher than that in lung tissue adjacent to nonmucinous bronchioalveolar carcinoma and mucinous bronchioalveolar carcinoma (P<0.01)，compared with pulmonary adenocarcinoma，the difference showed no statistical significance(P>0.05），node metastasis rate in nonmucinous bronchioalveolar carcinoma was significantly higher than that in mucinous bronchioalveolar carcinoma(P<0.01)，compared with pulmonary adenocarcinoma，the difference showed no statistical significance(P>0.05）.Twenty cases of nonmucinous bronchioalveolar carcinoma exhibited node metastasis，compared with non-metastasis group ，positive rate of VEGF-C protein showed statistical significance(P<0.05).Expression of VEGF-C mRNA in nonmucinous bronchioalveolar carcinoma was significantly higher than that in lung tissue adjacent to nonmucinous bronchioalveolar adenocarcinoma and mucinous bronchioalveolar carcinoma(P<0.01)，compared with pulmonary adenocarcinoma，it was dramatically lower(P<0.01). Conclusion Up-regulation of VEGF-C protein in nonmucinous bronchioalveolar carcinoma suggests that it may has similar invasiveness and metastasis characteristic with pulmonary adenocarcinoma，compared with mucinous bronchioalveolar carcinoma，node metastasis more easily occured in nonmucinous bronchioalveolar carcinoma.