Expression of D2-40 and survivin in Cervical Carcinoma and Their Relation to Prognosis

Objective To investigate the expression of D2-40 and survivin protein in cervical carcinoma and its relation to prognosis. Methods The expression of D2-40 and survivin protein in 97 cases of cervical carcinoma were investigated immunohistochemically，and average LVD marked by D2-40 antibody were examined by computer.Fifty six cases were followed up，in which the prognosis was studied with both univariate and multivariate analysis.The cases of cervical intraepithelial neoplasia，chronic cervicitis were compared in the investigation. Results The average LVD marked by D2-40 and expression of survivin protein were obviously different among three groups (P<0.01).D2-40 and survivin protein expression were associated with differentiated grade，aggressive degree，FIGO stage and lymph nodal involvement (P<0.01).The expression of D2-40 was positively associated with survivin protein (P<0.01).In the 56 cases with followed-up data，univariant analysis revealed that the average LVD marked by D2-40，expression of survivin，differentiated grade，aggressive degree，FIGO stage and lymph nodal involvement were correlated with the survival rate.Cox stepwise proportional hazards analysis showed that they were prognostic factors independently except aggressive degree. Conclusion D2-40 was highly expressed in cervical carcinoma，which suggested that D2-40 was closely related to the growth，development and metastasis of cervical carcinoma.And there was intimate correlation between expression of D2-40 and survivin protein in cervical carcinoma.They were independent prognostic factors independently.