Androgen Receptor Expression in Primary Breast Cancer and Its Relationship with Clinico Pathological Factors

Objective To research the expression of androgen receptor in the primary breast cancer and its relationship with clinicopathological factors. Methods AR，ER，PR，HER-2 and Ki-67 expression were evaluated in 520 primary breast cancers by using immunohistochemistry methods.Simultaneously patient's corresponding age，menstrual status，lymphnode metastasis，tumor size，pathological classification，clinical stage，tumor grade and other clinicopathological parameters.The chi-square test in SPSS 13.0 software was used on the above datas for statistical analysis. Results The positive rate of AR is 81.3%.The tumors with smaller size，lower grade，positive ER，positive PR all have higher AR(P=0.000，0.029，0.000，0.000).AR expression had no statistically significance with age，lymphnode metastasis，pathological type，TNM stage，vascular tumor thrombus，HER-2 and Ki-67 groups. Conclusion Androgen receptors are widely expressed in breast cancer.AR is an indicator showing lower malignant degree and better prognosis.New treatment modalities to aim at AR maybe considered to suppress the development of breast cancer with positive AR.