Expression and Clinical Significance of microRNA-31 in Primary Lung Cancer Tumor Tissues

Objective Detected the miR-31 expresssion level in tumor tissues and adjacent normal tissues to observe the relationship between miR-31 and the screening & diagnosis of lung cancer. Methods Using quantitative real-time RT-PCR to assess the miR-31 expression in lung cancer tumor tissues and adjacent normal tissues. Results The relative expression level of miR-31 is 6.48 folds in tumor tissues compared to adjacent normal tissues（P<0.001).The level in smoke patients specimen is 3.06 folds to non-smoke.The expression level of tumor major axis＞3 cm is higher than major axis≤3 cm in NSCLC (P=0.033).Whether the lymph nodes metastasis or not，there is no difference between them. Conclusion The outcomes that miR-31 was overexpressed in lung cancer，and the difference in accordance with tumor major axis as well as the relationship with cigarettes indicated miR-31 might be a biomarker for screening，diagnosis，and predicting the tumor axis.