Meta-analysis for Association between Polymorphism of COX-2 -1195G>A and Colorectal Cancer Susceptibility

Objective To evaluate the association between COX-2 -1195G>A polymorphism and colorectal cancer susceptibility. Methods Literatures on the case-control studies on the association between COX-2 -1195G>A and colorectal cancer susceptibility，were collected from PUBMED and CBM database and then pooled odds ratio(OR) was assessed by Meta-analysis.We also performed subgroup analysis and sensitivity analysis and publication bias test. Results Six studies with 2854 cases and 4250 controls were enrolled in this Meta-analysis.The pooled OR of AA+AG genotype compared to GG genotype under dominant model was 1.29(95%CI:1.09~1.54) with significant difference. Conclusion The COX-2 -1195G>A polymorphism was significantly association with the colorectal cancer susceptibility under the dominant model.