No Correlation between Expression of GPER and Prognosis of Patients with Primary Breast Cancer

Objective To research the relationships between expression of G-protein coupled estrogen receptor (GPER) and patient prognosis in primary mammary cancers. Methods GPER from 241 tissues of primary breast cancer patients was detected by immunohistochemistry relationships between the expression of GPER and each of clinicopathological factors were analyzed by Chi-square and t-test.After a median 44.6 months follow-up，relationships between GPER expression and patient prognosis were analyzed by Kaplan-Meier method. Results GPER expression rate was 64.7%.There was a significant relationship among GPER and ERα，PR(P<0.05)，while no statistically association between GPER and HER-2 as well as other clinicopathological variables (patients age，menstruation status，tumor size，TNM stage，histological grade and pathological type) (P>0.05).Disease-free survival and overall survival in patients with GPER+ tumors were longer than those in patients with GPER-（P>0.05）.There was no marked association between GPER expression and hormonal therapy resistance. Conclusion The expression of GPER was not significantly related with most clinicopathological variables and impact on prognosis of breast cancers patients，also not an independent prognostic determinant for breast carcinoma.