Expression of Hypoxia-inducible-factor-1α and Transcriptional Factor Snail in Rectal Cancer Induces Metastasis and Poor Prognosis

ObjectiveTo investigate the expression of HIF-1α and Snail proteins in rectal cancer and their significance in metastasis and prognosis．MethodsThe expression of HIF-1α and Snail proteins was detected by using immunohistochemical SABC method in 121 cases of rectal cancer tissues．ResultsThe positive rates of HIF-1α and Snail in rectal cancer were 58.7%(71/121) and 71.9%(87/121)，respectively the expression of HIF-1α and Snail were significantly related with the lymph node metastasis and TNM stage of rectal cancer (P＜0.05)．HIF-1α expression have significantly positive correlation with Snail expression(P＜0.05)． ConclusionThe overexpression of HIF-1α and Snail might be important biological marker for invasion and metastasis and prognosis of rectal carcinoma．