XRCC1 Polymorphisms and Lymphoma Risk:A Meta-analysis of Case-Control Studies

ObjectiveTo evaluate the association between X-ray repair cross-complementing group1(XRCC1) gene polymorphisms and lymphoma risk by means of Meta-analysis. Methods We searched PubMed,EMbase,Chinese National Knowledge Infrastructure,China Journal Full Text Database,Chinese Biomedical Literature Database up to Feb 2010,the references of eligible studies were searched by hand.Case-Control studies involving X-ray repair cross-complementing group1(XRCC1) genetic polymorphism and lymphoma risk were included.Data were extracted independently by two reviewers according to designed extraction.The Cochrane Collaboration's RevMan 5.0 software was applied for statistical analyses. Results A total of 11 studies involving 4 569 patients and 5 746 controls were included.The results of Meta-analysis showed no statistical difference in the frequencies of variant genotypes and wild homozygote of XRCC1 between the Non-Hodgkin's lymphoma patients and controls,but Gln/Gln+Arg/Gln gentype of codon 399 may increase the risk of Hodgkin's lymphoma(OR=1.31,95%CI ［1.02,1.69］). Conclusion The polymorphism at codon 399,194 and 280 of XRCC1 are not associated with Non-Hodgkin's lymphoma risk but Gln/Gln+Arg/Gln genotype of codon 399 may increase the risk of Hodgkin,s lymphoma.