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Adili·Salai, Patiguli·Aerxiding, LIU Yi, ZHANG Guo-qing, PANG Zuo-liang. Effect of Neo-adjuvant Chemotherapy with Surgery on Survival Ratio for Locally Advanced Non-small Cell Lung Cancer[J]. Cancer Research on Prevention and Treatment, 2011, 38(09): 1058-1061. DOI: 10.3971/j.issn.1000-8578.2011.09.022
Citation: Adili·Salai, Patiguli·Aerxiding, LIU Yi, ZHANG Guo-qing, PANG Zuo-liang. Effect of Neo-adjuvant Chemotherapy with Surgery on Survival Ratio for Locally Advanced Non-small Cell Lung Cancer[J]. Cancer Research on Prevention and Treatment, 2011, 38(09): 1058-1061. DOI: 10.3971/j.issn.1000-8578.2011.09.022

Effect of Neo-adjuvant Chemotherapy with Surgery on Survival Ratio for Locally Advanced Non-small Cell Lung Cancer

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  • Received Date: December 05, 2010
  • Revised Date: April 14, 2011
  • ObjectiveTo investigate the effect of Neo-adjuvant chemotherapy for locally advanced non -small cell lung cancer survival ratio. Methods 119 patients with locally advanced non-small cell lung cancer were divided into two groups:group A (59 cases,preoperative neoadjuvant chemotherapy group) and group B(control group 60 cases without neoadjuvant chemotherapy).Compared with the difference of survival rate,effective ratio and post-operation complication of the patients. Results The total effective rate of preoperative neoadjuvant chemotherapy group was 54.23%(32/59),down regulation rate of stage was 20.33%(12/59).Resective rate and radical rate of experimental group was 91.5% and 81.4%,high than control group.The 1-,3-,5-year survival rates were 79.66%,50.88%,21.43% in group A,and 71.19%,35.09%,14.29% in group B,there was statistically significant between the two groups(P<0.05).The average survival time was 32.909 months in group A and 28.046 months in group B,there was statistically significant between the two groups(P<0.05). Conclusion Compared with the first-operation group,neoadjuvant chemotherapy followed up surgery have advantages for locally advanced non-small cell lung cancer patients,it didn't add surgical complication and it is still safe and feasible.
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