Meta-analysis of Association of 8q24 rs1447295A/C Polymorphism and Risk of Prostate Cancer in Asian Men　

ObjectiveTo investigate the association of the rs1447295 locus polymorphism in the 8q24 chromosome and the risk of prostate cancer by means of Meta-analysis. MethodsAn electric search was performed in PubMed and CNKI database at the end of Dec 2009.All analyses were conducted with Review Manager Version 4.2 software. Results4 literatures with 3 different ethnic groups were studied, totally including the PCa(Prostate Cancer) group(1 391 cases) and the normal control(1 274 cases).The summary OR for studies with frequency of AA+CA genotype at rs1447295 locus in the 8q24 was 1.50(95%CI: 1.28~1.77，Z=4.92，P<0.00001). ConclusionThe meta-analysis suggests that the polymorphism at the rs1447295 locus of 8q24 might be a genetic risky factor for prostate cancer in Asian men.