Advanced Search
FENG Qing-qing, LIU Hong-mei, PENG Qiu-ping, KE Chuan-qing. Expressions of HK-Ⅱ, TS and Ki-67 and Their Significance in Young Colon Cancer Patients[J]. Cancer Research on Prevention and Treatment, 2011, 38(06): 663-665. DOI: 10.3971/j.issn.1000-8578.2011.06.014
Citation: FENG Qing-qing, LIU Hong-mei, PENG Qiu-ping, KE Chuan-qing. Expressions of HK-Ⅱ, TS and Ki-67 and Their Significance in Young Colon Cancer Patients[J]. Cancer Research on Prevention and Treatment, 2011, 38(06): 663-665. DOI: 10.3971/j.issn.1000-8578.2011.06.014

Expressions of HK-Ⅱ, TS and Ki-67 and Their Significance in Young Colon Cancer Patients

More Information
  • Received Date: May 18, 2010
  • Revised Date: September 05, 2010
  • ObjectiveTo investigate the expressions of hexokinase type Ⅱ (HK-Ⅱ), thymidylate synthase (TS) protein and Ki-67 nuclear antigen (Ki-67), and to reveal their clinical significance in young patients with colon cancer. MethodsThe protein expressions of HK-Ⅱ, TS and Ki-67 in 78 patients (≤ 40 years ) with colon cancer and 75 patients (> 40 years ), were detected by immunohistochemical technique with retrospective comparison. ResultsThe positive expression rates of HK-Ⅱ and TS were 82.1% (64/78) and 65.3% (49/75), 69.2% (54/78) and 52.0% (39/75), respectively, in young group and older group. Moreover, the Ki-67 proliferation indexes of both groups were (59.1±3.0)% and (48.5±3.2)%, respectively. Compared the young group with the older group, there were significant differences in the three positive expressions (both, P<0.01). Moreover, compared these positive expressions of HK-Ⅱ, TS and Ki-67 with those negative expressions in the young colon cancer patients, there were significant differences in cancer's differentiation and stage (both, P<0.01). The positive expression of HK-Ⅱ was consistent with the positive expressions of TS and Ki-67, respectively, in young patients with colon cancer. Conclusion The positive protein expressions of HK-Ⅱ, TS and Ki-67 may be malignant biomarkers.
  • Related Articles

    [1]CHEN Lijun, CHEN Jingqi, ZENG Bohang. Correlation of CD68+ Tumor-associated Macrophages Number with Ki-67 Expression and Prognosis of Patients with Primary Hepatocellular Carcinoma[J]. Cancer Research on Prevention and Treatment, 2016, 43(9): 774-778. DOI: 10.3971/j.issn.1000-8578.2016.09.009
    [2]LI Wen, FENG Yanlin. Valuation of SUVmax, Ki-67, p53 and EGFR in Predicting Effect of Neoadjuvant Chemotherapy on Triple-negative Breast Cancer Patients[J]. Cancer Research on Prevention and Treatment, 2016, 43(1): 45-47. DOI: 10.3971/j.issn.1000-8578.2016.01.010
    [3]YAN Su, LI Bin, MA Xuxiang, MA Yingcai, XIONG Yuanzhi, GUO Xinjian, MA Yubin, YU Pengjie, WU Junqi, XIE Dawei, ZHAO Junhui, WU Huixian. Clinicopathological Characteristics of Young Gastric Cancer Patients in Hehuang Valley[J]. Cancer Research on Prevention and Treatment, 2015, 42(05): 502-505. DOI: 10.3971/j.issn.1000-8578.2015.05.018
    [4]ZHANG Cui-cui, WANG Jing, LI Kai. Characteristics and Prognostic Analysis of 60 Young Patients with Lung Cancer[J]. Cancer Research on Prevention and Treatment, 2011, 38(03): 274-277. DOI: 10.3971/j.issn.1000-8578.2011.03.009
    [5]LIANG Xu-dong, SHI Xiao-feng, JIA Zong-qi. Detection andSignificance of PTEN, NFκB andKi-67 in Gastric Cancer[J]. Cancer Research on Prevention and Treatment, 2010, 37(03): 326-629. DOI: 10.3971/j.issn.1000-8578.2010.03.023
    [6]ZHONG Wei-ming, MA Li-ping, CAI Yong-lin, LIANG Wei, CHEN Wan-sheng, HUANG Zhuo, YU Hong, TAN Bi-fang. Relationship between Expression of Ki-67 Protein and Radiosensitivity of Nasopharyngeal Carcinoma[J]. Cancer Research on Prevention and Treatment, 2010, 37(02): 195-196. DOI: 10.3971/j.issn.1000-8578.2010.02.019
    [7]SHI Guo-qing, ZHAO Kui, WANG Hong, LIU Mo-rong. Expression of Gastrin and Ki-67 in Gastric Cancer and Precancerous Pesions[J]. Cancer Research on Prevention and Treatment, 2009, 36(09): 756-758. DOI: 10.3971/j.issn.1000-8578.2009.09.011
    [8]HE Yan-jiao, LIU Zhao-xia, LI Hong-li, YU Jin, LI Guang. Expression and Significance of E-cadherin and Ki-67 in Colorectal Carcinoma[J]. Cancer Research on Prevention and Treatment, 2007, 34(09): 699-702. DOI: 10.3971/j.issn.1000-8578.2529
    [9]ZHENG Lei, HAN Yue-wu. Antisense Oligodeoxyribonucleotide Target Ki-67 Inhibits Proliferation of Human Hepatocellucar Carcinoma Cell HEPG-7402 in Vitro[J]. Cancer Research on Prevention and Treatment, 2006, 33(12): 862-864. DOI: 10.3971/j.issn.1000-8578.354
    [10]DENG Jie, CAO Dun-wen, LIU Ming-qiu, ZHU Run-qing, CHEN Hong-lei, CHEN Dao-ying, WANG Ji-e. Expression of p73, PTEN and Ki-67 Proteins in Endometrioid Adenocarcinoma and Their Significance[J]. Cancer Research on Prevention and Treatment, 2006, 33(11): 811-813. DOI: 10.3971/j.issn.1000-8578.374

Catalog

    Article views (2221) PDF downloads (489) Cited by()

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return