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ZHAO Hai-yan, HU Jie, WANG Ya-juan, WU Gong-fa, HAN Hui-xia. Significance of Tiam1 and SNAI1 in EMT of Human Colorectal Carcinoma[J]. Cancer Research on Prevention and Treatment, 2011, 38(06): 654-657. DOI: 10.3971/j.issn.1000-8578.2011.06.012
Citation: ZHAO Hai-yan, HU Jie, WANG Ya-juan, WU Gong-fa, HAN Hui-xia. Significance of Tiam1 and SNAI1 in EMT of Human Colorectal Carcinoma[J]. Cancer Research on Prevention and Treatment, 2011, 38(06): 654-657. DOI: 10.3971/j.issn.1000-8578.2011.06.012

Significance of Tiam1 and SNAI1 in EMT of Human Colorectal Carcinoma

  • ObjectiveTo explore the significance of Tiam1 and SNAI1 in human colorectal carcinoma. MethodThe expressions of Tiam1, SNAI1 and E-cadherin were detected by immunohistochemistry in normal colorectal epithelium, colorectal carcinoma and lymphatic metastasis of colorectal carcinoma. ResultsThe expression rates of Tiam1 and SNAI1 in colorectal carcinoma were apparently higher than that in normal colorectal epithelium (P=0.000;P=0.000), and correlated with the degree of tumor differentiation (P=0.014;P=0.014),The expression rates of Tiam1 and SNAI1 in lymphatic metastasis were apparently higher than that in colorectal carcinoma (P=0.002;P=0.001).The expression rate of E-cadherin in colorectal carcinoma was remarkably lower than that in normal colorectal epithelium (P=0.000), and correlated with the degree of tumor differentiation (P=0.000). The expression rate of E-cadherin in lymphatic metastasis was remarkably lower than that in colorectal carcinoma (P=0.007). Tiam1 was positively correlated with SNAI1(r=0.584,P=0.000). Tiam1 and SNAI1 were negatively correlated with E-cadherin(r=-0.324,P=0.000;r=-0.420,P=0.000)). ConclusionTiam1 and SNAI1 may promote invasion and metastasis of colorectal carcinoma by inducing EMT.
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