Effects of High-risk Human Papillomavirus DNA Viral Load and Age in Screening of Cervical Lesions

ObjectiveTo investigate the effects of high-risk human Papillomavirus(HR-HPV) DNA viral load and age in screening of cervical lesions．MethodsHR-HPV DNA viral in a total of 1 301 cases were detected by hybrid capture Ⅱ testing 454 cases received cervical biopsy because of high-risk factors. ResultsOverall HR-HPV infection prevalence was 51.04% (664/1301), furthermore in women ≤25 years old it was the highest among all age groups(55.68%,49/88). In women aged ≤35, the correlation coefficient between viral load and cervical lesion severity was not statistically significant (P=0.6207). In women aged＞35, it had significantly the constituent ratio differences of cervical lesion severity between HR-HPV＜100 pg/μl and HR -HPV≥100 pg/μl (P<0.0001). In women aged＞35 with HR-HPV≥100 pg/μl，the prevalence of CIN Ⅲ and invasive cervical carcinoma was higher than those in others. While the prevalence of Chronic cervicitis and CINⅠ in HR-HPV <100 pg/μl is higher than those in others.It had unstable trend about the prevalence of CINⅡ in all population. ConclusionIt could improve the validity and sensitivity of cervical lesions diagnosis by clinical screening high-risk human papillomavirus DNA viral load.