Expression and Prognostic Significance of Nuclear PTEN in Gastric Cancer

ObjectiveTo evaluate the expression of nuclear PTEN in gastric cancer tissues and identify whether nuclear PTEN was a prognostic factor through analysis for the correlation with clinipathological features. MethodsThe expression of nuclear PTEN proteins was detected by tissue array and immunohistochemistry in 85 cases of gastric cancer . The relationships between nuclear PTEN expression and their clinipathological features were evaluated. ResultsThe over expression rate of nuclear PTEN in gastric cancer was 71.76% (61/85). A significant positive correlation was observed between nuclear PTEN and prognosis (P<0.05). Nuclear PTEN was significantly related to Lauren's classification (P=0.011) and lymph node metastasis (P=0.023). ConclusionNuclear PTEN was over expressed and might be a prognostic factor and a potential therapy target in gastric cancer.