Experiment Research on Anti-tumor Effects of Perindopril on S180 Tumor

ObjectiveTo investigate the anti-tumor effects of perindopril on growth of S180 tumor in mice. Methods The mice loaded S180 cell line were randomly divided into 3 groups.The perindopril (0.50 mg/ml) angiotensin Ⅱ (AngⅡ 0.25 mg/ml) and sistilled water(blank control)were administered by gavage daily for 10 days.The anti-tumor effects of perindopril were evaluated by body weight, food-intake and tumor weight.MVD,VEGF,AngⅡ expression were detected by HE and immunohistochemical staining. Results The mice body weights were increased obviously, and no significant difference among three groups（P>0.05 ）. Compared with control group, tumor growth of perindorpril (0.50mg/ml)group was remarkably inhibited（P<0.05）, and AngⅡ group was remarkably increased（P<0.05）.MVD, VEGF, AngⅡ expressions were decreased in perindorpril(0.50mg/ml) group. MVD and VEGF expressions were increased in AngⅡ group(0.25mg/ml) （P<0.05）. Conclusion The perindorpril was able to significantly inhibit the growth of S180 tumor throngh inhibiting tumor angiogenesis induced by AngⅡ, VEGF and MVD down-regulation.