Detection and Clinical Implications of Serum Angiopoietins in Multiple Myeloma Patients

ObjectiveTo explore the relationship of angiopoietins (Angs) with multiple myeloma(MM) and its clinical significance. Methods The serum concentration of Angs in different periods was detected by double-antibody sandwich enzyme-linked immunosorbent assays technique in 60 cases of MM patients and 20 controls.The associations between the serum cytokines levels with MM stages(Ⅱ～ Ⅲ), tumor load and the curative effect were observed,respectively. Results Pretreatment MM had significantly higher serum Ang-2 levels than controls.Serum Ang-1 levels in pretreatment MM had no significant difference compared with controls.Pretreatment serum Ang -2 levels were significantly lower in stage Ⅱ than in stage Ⅲ of MM.There weas significant difference between the different tumor load.In the patients responding to chemotherapy,Ang-2 serum levels was significantly decreased, while serum Ang-1 levels was no significant difference. In the patients who did not achieve a remission, there was no significantly change in serum Ang-1 levels and serum Ang-2 levels. Conclusion Serum levels of Ang-2 detection in MM patients is a certain extent significance to study of the pathogenesis of MM, the condition evaluation, efficacy monitoring, and outcome of prediction.