Expression of HGF，c-Met and VEGF-C in Cervical Carcinoma

ObjectiveTo investigate the expression level of hepatocyte growth factor（HGF) and its receptor, the proto-oncogene c-Met, and vascular endothelial growth factor-C(VEGF-C) in cervical carcinoma. Methods The mRNA levels of HGF,c-Met and VEGF-C were detected by Real Time fluorescence Quantitative PCR(FQ RT-PCR) method in 43 cervical carcinoma tissues，30 cervical intraepithelial neoplasm Ⅲ（CINⅢ）tissues and 27 normal cervical,respectively. Results The positive expression of HGF mRNA,c-Met mRNA and VEGF-C mRNA increased remarkably from normal tissue to CINⅢ and then to cervical carcinoma (P<0.05)．In cervical carcinoma, the expression of these three genes was positive correlated with the clinical stage,tumor size,the invasion of deep muscular layer and the lymph node metastasis (P<0.05).These three genes were significant positive correlation (P<0.01). Conclusion Over expression of HGF, c-Met and VEGF-C together may participate in the invasion and metastasis of cervical carcinoma.To investigate them together would be facilitated to the treatment and prognosis of cervical carcinoma.